Table 2 Gene functions in the lung and 2nd organ
From: Identification of rat lung – prominent genes by a parallel DNA microarray hybridization
Gene | Function in lung | 2nd organ (location) | Function in 2nd organ |
|---|---|---|---|
Ager | Oxidant response | (AEC I)* | |
ICAM-1 | AEC-leukocyte adhesion | (AEC) | |
K19 | Cell differentiation | (AEC) | |
SP-D, BD-2 | Defense, surfactant | (AEC II) | |
slc42a2 | Surfactant synthesis? | (AEC II) | |
Calb3 | Ca2+ homeostasis | ||
Mapk13 | Inflammatory response | ||
Slc29a1 | Ion transporter? | ||
Lcn2 | Apoptosis? | ||
Crhr1 | Hormone receptor? | ||
Ddr2 | Collagen remodeling | ||
Mg50 | Tumor pathogenesis? | ||
Tnni2, tni3 | Lung veins [35] | Heart | Muscle contrast [36;37] |
Cox6a2, Cox8h | Energy supply? | Heart | Muscle energy supply [38] [39] |
Anp | Asthma? [40] | Heart | Proliferation control [41] |
Aqp5 | Edema? | Liver | Fluid homeostasis [42] |
Ces3, gpt | Injury and repair [43] [44] | Liver | Injury [45] |
Cyp2615 | Oxidantive stress [46] | Liver | Xenobiotic metabolism? |
Cldn3 | Epithelia barrier [47] | Liver | Paracellular permeability [48] |
S100a18 | Cell migration [49;50] | Spleen | Cell motility? |
Iga, Igm [51] [52] | Immune response | Spleen | Immune response |
Cd37 [53] | Proliferation? | Spleen | Proliferation? |
Cathepsin Y | Surfactant process? [54] [55] | Spleen | Endopeptidase [56;57] |
Fas, Alp | AEC II injury [58] | Kidney | Renal injury [59] [60] |
Tpa66 | Inflammatory [61] | Kidney | Anti-arterial thrombosis [62] |
Nf2 [63] | Tumor supression | Kidney | Tumor suppression |