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Figure 4 | BMC Genomics

Figure 4

From: Multilocus analysis of SNP and metabolic data within a given pathway

Figure 4

Pattern recognition: Search for combination of SNPs and physiological parameters associatedwith a given metabolic trait. On top bar diagrams illustrating the distribution of all possible combinations of traits in the metabolic groups below or a bove a given threshold (given in a sqare frame above each bar diagram). (A) DHEA-SO4 levels Cyp1a1m1 = mut/mut and GSTT1 = mut and Age>64 and Weight<75, CorrMAX 0.54(49/56) p < 0.0001, Age – Weight, CorrMAX 0.44 p < 0.002 Infogram: CYP1A1m1: Black = wt/wt Yellow = mut/mut Red = wt/mut; GSTT1 Black= wt/wt or wt/mut Yellow = mut/mut; Age Yellow = <64 Black = >64; Weight Yellow = >75 Black = <75 (B). E1 (Estrone) levels: The genotype combination CYP11 = mut and GSTM1 = wt is present among 12 patients with a level above 68 pmol/l, but non of the patients with a level below 68 pmol/l, CorrMAX 0.36(53/52) p < 0.05. (C) Estrone sulphate, GSTM1 – Weight(75 kg), CorrMAX 0.43(43/62), p < 0.003 Infogram1: -GSTM1 Black = wt/wt or wt/mut Yellow = mut/mut; Weight Yellow = <75 Black = >75. (D) Sex hormone binding globulin, HSDA3T = mut/mut-CYP1B1A119S = mut/mut-comt1 = mut/mut. CorrMAX 0.38(59/49), p < 0.05 Infogram: CYP1B1A119S Red = wt/wt, Yellow = mut/mut, Black = wt/mut, COMT1: Red = wt/wt, Yellow = mut/mut, Black = wt/mut.

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