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Table 4 Statistical significance of distributions of genotypes in the listed estradiol metabolizing enzymes in below and above median levels of metabolites DHEA, dihydroepiandrostenedione, DHEA-SO4, dihydroepiandrostenedione sulfate, androstenedione, testosterone, E1, estrone, E2, estradiol, E1S, estrone- sulphate, SHBG, sex hormone binding globulin. NS – not significant.

From: Multilocus analysis of SNP and metabolic data within a given pathway

   Below and above median values
Gene/SNP   DHEA DHEA-SO4 Androstenedione Testosterone E1 E2 E1S SHBG
HSD DEL 5'flanking 12 bp deletion NS NS NS NS NS NS NS NS
HSD A3T 5'flanking (AAAT)n NS NS NS p < 0.053 NS NS NS NS
CYP17 5'flanking NS NS NS NS NS NS NS NS
CYP19UTRSNP1 3'untranslated NS NS NS NS p < 0.037 p < 0.048 NS NS
CYP19UTRSNP2 3'untranslated NS NS NS NS NS NS NS NS
CYP19 UTRSNP3 3'untranslated NS NS NS p < 0.089 p < 0.014 p < 0.013 NS NS
CYP11 5'flanking NS P = 0.042 p < 0.053 NS p < 0.003* p < 0.004* NS NS
CYP1B1 R48G coding nonsynon R48G NS p < 0.082 NS NS p < 0.049 p < 0.082 p < 0.042 NS
CYP1B1 A119S coding nonsynon A119S NS NS NS NS p < 0.073 p < 0.002 NS NS
CYP1B1 V432L coding nonsynon V432L NS NS NS NS NS NS NS NS
CYP1A1 m1 3'untranslated NS NS NS NS NS NS NS NS
CYP1A1 m2 coding nonsynon I462V NS p < 0.044 NS NS NS NS NS NS
CYP1A1 m3 3'untranslated NS NS NS NS NS NS NS NS
CYP1A1 m4 coding nonsynon T461N NS NS NS NS p < 0.017 NS NS NS
COMT coding nonsynon V158M NS NS p < 0.02 NS NS NS NS NS
GSTM1 gene deletion NS NS NS NS NS NS NS NS
GSTT1 gene deletion NS NS NS NS NS NS NS NS
GSTp1 coding nonsynon NS NS NS NS NS NS NS NS
  1. *ANOVA analysis