Multilocus analysis of SNP and metabolic data within a given pathway

BMC Genomics

Table 4 Statistical significance of distributions of genotypes in the listed estradiol metabolizing enzymes in below and above median levels of metabolites DHEA, dihydroepiandrostenedione, DHEA-SO4, dihydroepiandrostenedione sulfate, androstenedione, testosterone, E1, estrone, E2, estradiol, E1S, estrone- sulphate, SHBG, sex hormone binding globulin. NS – not significant.

		Below and above median values
Gene/SNP		DHEA	DHEA-SO4	Androstenedione	Testosterone	E1	E2	E1S	SHBG
*HSD DEL*	5'flanking 12 bp deletion	NS	NS	NS	NS	NS	NS	NS	NS
*HSD A3T*	5'flanking (AAAT)n	NS	NS	NS	p < 0.053	NS	NS	NS	NS
*CYP17*	5'flanking	NS	NS	NS	NS	NS	NS	NS	NS
*CYP19UTRSNP1*	3'untranslated	NS	NS	NS	NS	p < 0.037	p < 0.048	NS	NS
*CYP19UTRSNP2*	3'untranslated	NS	NS	NS	NS	NS	NS	NS	NS
*CYP19 UTRSNP3*	3'untranslated	NS	NS	NS	p < 0.089	p < 0.014	p < 0.013	NS	NS
*CYP11*	5'flanking	NS	P = 0.042	p < 0.053	NS	p < 0.003*	p < 0.004*	NS	NS
*CYP1B1* R48G	coding nonsynon R48G	NS	p < 0.082	NS	NS	p < 0.049	p < 0.082	p < 0.042	NS
*CYP1B1* A119S	coding nonsynon A119S	NS	NS	NS	NS	p < 0.073	p < 0.002	NS	NS
*CYP1B1* V432L	coding nonsynon V432L	NS	NS	NS	NS	NS	NS	NS	NS
*CYP1A1 m1*	3'untranslated	NS	NS	NS	NS	NS	NS	NS	NS
*CYP1A1 m2*	coding nonsynon I462V	NS	p < 0.044	NS	NS	NS	NS	NS	NS
*CYP1A1 m3*	3'untranslated	NS	NS	NS	NS	NS	NS	NS	NS
*CYP1A1 m4*	coding nonsynon T461N	NS	NS	NS	NS	p < 0.017	NS	NS	NS
*COMT*	coding nonsynon V158M	NS	NS	p < 0.02	NS	NS	NS	NS	NS
*GSTM1*	gene deletion	NS	NS	NS	NS	NS	NS	NS	NS
*GSTT1*	gene deletion	NS	NS	NS	NS	NS	NS	NS	NS
*GSTp1*	coding nonsynon	NS	NS	NS	NS	NS	NS	NS	NS

ISSN: 1471-2164