Table 5 Searching for optimal thresholds approach to identify genotypes associated with quantitative trait (all SNPs with p-value < 0.05). Partitioning A shows significant results for one optimal threshold (two partitions), and Partitioning B shows the results for two optimal thresholds (three partitions). The calculated p-values take into account the multiple search over all possible thresholds as described in [3].
From: Multilocus analysis of SNP and metabolic data within a given pathway
Partitioning A | Partitioning B | ||
|---|---|---|---|
Metabolite | SNP | p-value | p-value |
DHEA | CYP1B1 R48G | NS | 0.022 |
E1 | CYP1B1 A119S | 0.039 | 0.0045 |
E1S | CYP1B1 A119S | NS | 0.043 |
Androstenedione | CYP19 UTRSNP1 | 0.042 | NS |
DHEA-SO4 | cyp1A1 m1 | NS | 0.010 |
DHEA-SO4 | cyp1A1 m2 | 0.022 | 0.011 |
E1 | cyp1A1 m4 | 0.042 | 0.028 |