Figure 2

PZPMs in humans, C. elegans and A. thaliana. The alignments were constructed by T-coffee and refined manually as necessary. All PZPMs found in C. elegans and A. thaliana are shown. For human sequences, at least one representative of each identified PZPM family is shown. There are multiple homologs/paralogs in each family except NSD1 that have been omitted for clarity (3 BRD1-like molecules, 3 Jade-like molecules, 3 AF10-like molecules, 2 GASC1-like molecules). Human sequences are given with GenBank accession numbers, C. elegans sequences with wormbase accession numbers, and A. thaliana sequences with chromosomal addresses. All identifiers can be used as queries at [30]. The first portion of the PZPM (solid ligand lines) is identified by Pfam as a PHD. The remainder of the PZPM (dashed ligand lines) is not identified by Pfam but appears to comprise a previously undefined C2HC zinc knuckle or ribbon followed by a PHD-like derivative. It should be noted that the entire domain is conserved amongst all PZPM proteins, and for functional considerations it should not be viewed as simply a PHD.