Reconstructed REP sequences at the insertion sites of ISs with type 1 association with REP sequences. The reconstructed REP sequences displayed in the figure have generally gone unnoticed because it is needed to join the two fragments that are intervened by the IS element to reconstruct the complete REP sequence. The figure shows the multiple alignment of the reconstructed REP sequences with the conserved bases shadowed in blue. The canonical REP sequence is at the bottom of each alignment. One of the REP sequence fragments is in pink, the direct repeat generated in the transposition event is shadowed in blue, and the other REP sequence fragment is in aquamarine. The palindromy of canonical REP sequences is indicated in bracket notation.