Figure 5

Sequence logo representing the Cre- loxP consensus site. A total of 6,248 spacers that participated in successful recombination reactions were used to generate a sequence "logo" representing the nucleotide preference of Cre recombinase in the spacer region. Information content (I) as each spacer position was calculated (see Methods for details). Base height (H) represents nucleotide frequency and at each position in the loxP spacer region.