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Table 2 The top 25 down-regulated genes in the DoxHPC lines after dox withdrawal. The columns 36 h, 72 h and 96 h refer to hours after dox withdrawal and include the M-values (=log2 [expression in differentiated/expression in undifferentiated]). The M-value of Lhx2 down-regulation is equivalent to a fold-change of approximately 8.

From: Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression

Symbol Gene name Genbank Unigene ID Gene ID 36 h 72 h 96 h
Lhx2 LIM homeobox protein 2 CX208629 Mm.142856 16870 -2.95 -2.71 -3.06
Serpina3g Serine (or cysteine) proteinase inhibitor, clade A, member 3G CX234493 Mm.264709 20715 -2.02 -2.41 -2.53
Bpgm 2,3-bisphosphoglycerate mutase CX200054 Mm.282863 12183 -1.63 -2.07 -2.06
Csrp2 Cysteine and glycine-rich protein 2 CX241650 Mm.2020 13008 -1.29 -1.28 -1.31
Plscr1 Phospholipid scramblase 1 CX230405 Mm.14627 22038 -1.21 -1.48 -1.64
Mal Myelin and lymphocyte protein, T-cell differentiation protein CX219564 Mm.39040 17153 -1.16 -1.14 -1.2
- Unknown CX220013 - - -1.13 -1.2 -1.1
Sdh1 Sorbitol dehydrogenase 1 CX204086 Mm.371580 20322 -1.1 -1 -1
Upp1 Uridine phosphorylase 1 CX218174 Mm.4610 22271 -1.09 -1.2 -1.33
Syne2 Synaptic nuclear envelope 2 CX218234 Mm.26652 319565 -1.02 -1.12 -1.12
Catnd2 DNA segment, KIST 4 CX237590 Mm.321648 18163 -1 -0.95 -1.02
Galnt2 UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 2 CX228653 Mm.33808 108148 -1 -1.1 -1.22
Etv5 Ets variant gene 5 CX240212 Mm.155708 104156 -0.99 -1.06 -1.16
Myo1b Myosin IB CX206461 Mm.3390 17912 -0.99 -1.17 -1.23
Parp8 RIKEN cDNA 5930433N17 gene CX230711 Mm.274466 52552 -0.96 -0.83 -0.66
Laptm4b Lysosomal-associated protein transmembrane 4B CX240664 Mm.197518 114128 -0.92 -0.91 -0.95
Nrgn Neurogranin CX240939 Mm.335065 64011 -0.91 -0.9 -1.18
B230104P22Rik RIKEN cDNA B230104P22 gene CX241478 Mm.25874 77976 -0.89 -0.98 -0.99
1810009M01Rik RIKEN cDNA 1810009M01 gene CX239344 Mm.28385 65963 -0.89 -0.93 -1.07
Sox4 SRY-box containing gene 4 CX240226 Mm.240627 20677 -0.88 -1.04 -1.06
2810408E11Rik RIKEN cDNA 2810408E11 gene CX242247 Mm.291015 106200 -0.86 -0.88 -0.97
Mfge8 Milk fat globule-EGF factor 8 protein CX239348 Mm.1451 17304 -0.86 -0.88 -1.01
Serpina3n Serine (or cysteine) proteinase inhibitor, clade A, member 3N CX200330 Mm.22650 20716 -0.86 -1.07 -1.15
Vim Vimentin CX235238 Mm.268000 22352 -0.85 -0.83 -0.81
Cklfsf4 Chemokine-like factor super family 4 CX206907 Mm.29658 97487 -0.85 -1.08 -1.16