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Table 2 The top 25 down-regulated genes in the DoxHPC lines after dox withdrawal. The columns 36 h, 72 h and 96 h refer to hours after dox withdrawal and include the M-values (=log2 [expression in differentiated/expression in undifferentiated]). The M-value of Lhx2 down-regulation is equivalent to a fold-change of approximately 8.

From: Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression

Symbol

Gene name

Genbank

Unigene ID

Gene ID

36 h

72 h

96 h

Lhx2

LIM homeobox protein 2

CX208629

Mm.142856

16870

-2.95

-2.71

-3.06

Serpina3g

Serine (or cysteine) proteinase inhibitor, clade A, member 3G

CX234493

Mm.264709

20715

-2.02

-2.41

-2.53

Bpgm

2,3-bisphosphoglycerate mutase

CX200054

Mm.282863

12183

-1.63

-2.07

-2.06

Csrp2

Cysteine and glycine-rich protein 2

CX241650

Mm.2020

13008

-1.29

-1.28

-1.31

Plscr1

Phospholipid scramblase 1

CX230405

Mm.14627

22038

-1.21

-1.48

-1.64

Mal

Myelin and lymphocyte protein, T-cell differentiation protein

CX219564

Mm.39040

17153

-1.16

-1.14

-1.2

-

Unknown

CX220013

-

-

-1.13

-1.2

-1.1

Sdh1

Sorbitol dehydrogenase 1

CX204086

Mm.371580

20322

-1.1

-1

-1

Upp1

Uridine phosphorylase 1

CX218174

Mm.4610

22271

-1.09

-1.2

-1.33

Syne2

Synaptic nuclear envelope 2

CX218234

Mm.26652

319565

-1.02

-1.12

-1.12

Catnd2

DNA segment, KIST 4

CX237590

Mm.321648

18163

-1

-0.95

-1.02

Galnt2

UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 2

CX228653

Mm.33808

108148

-1

-1.1

-1.22

Etv5

Ets variant gene 5

CX240212

Mm.155708

104156

-0.99

-1.06

-1.16

Myo1b

Myosin IB

CX206461

Mm.3390

17912

-0.99

-1.17

-1.23

Parp8

RIKEN cDNA 5930433N17 gene

CX230711

Mm.274466

52552

-0.96

-0.83

-0.66

Laptm4b

Lysosomal-associated protein transmembrane 4B

CX240664

Mm.197518

114128

-0.92

-0.91

-0.95

Nrgn

Neurogranin

CX240939

Mm.335065

64011

-0.91

-0.9

-1.18

B230104P22Rik

RIKEN cDNA B230104P22 gene

CX241478

Mm.25874

77976

-0.89

-0.98

-0.99

1810009M01Rik

RIKEN cDNA 1810009M01 gene

CX239344

Mm.28385

65963

-0.89

-0.93

-1.07

Sox4

SRY-box containing gene 4

CX240226

Mm.240627

20677

-0.88

-1.04

-1.06

2810408E11Rik

RIKEN cDNA 2810408E11 gene

CX242247

Mm.291015

106200

-0.86

-0.88

-0.97

Mfge8

Milk fat globule-EGF factor 8 protein

CX239348

Mm.1451

17304

-0.86

-0.88

-1.01

Serpina3n

Serine (or cysteine) proteinase inhibitor, clade A, member 3N

CX200330

Mm.22650

20716

-0.86

-1.07

-1.15

Vim

Vimentin

CX235238

Mm.268000

22352

-0.85

-0.83

-0.81

Cklfsf4

Chemokine-like factor super family 4

CX206907

Mm.29658

97487

-0.85

-1.08

-1.16