Mutation | Function | MTH | MTC | MB |
---|---|---|---|---|
I Mutation leading to ORF splitting (33) | ||||
a) Fusion with overlaping orf (5) | Â | Â | Â | Â |
G4 ↔ 5 | Membrane protein | *Rv0192A (100), Rv0192 (366) | MT0202 (366), 2 nd might be 100aa # | Mb0198 (352) |
G4 ↔ 5 | Membrane protein mce2b | Rv0590A (84), *Rv0590 (275) | MT0619 (287), 2 nd might be 84 aa # | Mb0605 (343) |
G7↔11 | FrdB, frdC | *Rv1553 (247), *Rv1554 (126) | MT1604 (247), MT1605 (126) | Mb1579 (374) |
T4↔5 | Hypothetical protein | *Rv3338 (214) *Rv3337 (128) | MT3441 (248) | Mb3370 (297) |
T2↔3 | Cut5a, cut5b truncated cutinase | Rv3724A (80), *Rv3724B(187) | MT3827 (207) | Mb3751 (233) |
b) Fusion with non-overlaping orf (4) | ||||
T5↔4 | GmhA | *Rv0113 (196), *Rv0114 (190) | MT0122 (420) | Mb0117 (196) Mb0118 (190) |
G5↔6 | Pks1, pks15 polyketide synthase | *Rv2946c (1616), *Rv2947c(496) | MT3018 (1620), MT3021.1 (496) | Mb2971c (2112) |
CG3↔2 | Hypothetical protein | *Rv2974c (470), *Rv2975c (84) | MT3052 (470), MT3052.1(92) | Mb2999c (553) |
T2↔3 | *dTDP-glucose 4,6-dehydratase | Rv3784 (326), *Rv3785 (357) | MT3893 (712) | Mb3813 (326), Mb3814 (357) |
c) Fission with overlaping orf (8) | ||||
G4↔5 | Flavo protein, electron acceptor, | Rv2251A (139) *Rv2251(475) | MT2311 (529) | Mb2275 (529) |
G5↔6 | Conserved hypothetical protein | *Rv2879c (189) Rv2880c (275) | MT2947 (364) | Mb2904c (364) |
G4↔3 | Conserved hypothetical protein | *Rv0740 (175) | MT0765 (82), MT0766 (120) | 31791926 (175) |
G3↔2 | fusA2 | *Rv0120c (714) | MT0128 (714) | Mb0124c (597), Mb0125c (117) |
G2 ↔ 3 | *Pks6 | Rv0405 (1402) | MT0418 (1402) | Mb0412 (460), Mb0413 (946) |
T6↔7 | PstB | *Rv0933 (276) | MT0960 (276) | Mb0957 (71), Mb0958 (213) |
C2↔ 3 | *drug transporter | Rv1877 (687) | MT1926 (687) | Mb1908 (511), Mb1909 (404) |
C6↔5 | LppO | *Rv2290 (171) | MT2347 (192) | Mb2312 (51), Mb2313 (121) |
d) Fission with non-overlaping orf (16) | ||||
T5↔4 | aceAa, aceAb | *Rv1915 (367 *Rv1916 (398) | MT1966 (766) | Mb1950 (766) |
G5↔6 | Conserved hypothetical protein | *Rv2561 (97) *Rv2562 (129) | MT2638 (212) | Mb2591 (245) |
T2↔ 3 | Conserved transmembrane protein | Rv3453 (110), *Rv3454 (422) | MT3561 (562) | Mb3483 (561) |
C5↔ 4 | mmpL1 | *Rv0402c (958) | MT0412 (958) | Mb0408c (367), Mb0409c (591) |
C7↔6 | Hypothetical | *Rv0698 (203) | Might be 203 aa # | Mb0717 (109), Mb0718 (77) |
T3↔2 | 3-ketosteroid-delta-1-dehydrogenase | *Rv0785 (566) | MT0809 (566) | Mb0807 (191), Mb0808 (368) |
T2↔3 | cobL | Rv2072c (390) | MT2132 (390) | Mb2098c (294), Mb2099c (62) |
TG2↔1 | *Probable transposase | Rv2424c (333) | MT2497 (333) | Mb2447c (230), Mb2448c (97) |
G7↔15 | PE_PGRS | *Rv2490c (1660) | MT2564 (1665) | Mb2517c (1150), Mb2518c (509) |
GC3↔2 | transglutaminase family protein | Rv2566 (1140) | MT2642 (1156) | Mb2595 (533), Mb2596 (597) |
T4↔ 3 | ugpA | *Rv2835c (303) | MT2901 (303) | Mb2859c (180), Mb2860c (123) |
C2↔3 | fadE22 | *Rv3061c (721) | MT3147 (721) | Mb3087c (600), Mb3088c (114) |
C4↔3 | mesT | *Rv3176c (318) | MT3265 (339) | Mb3201c (105), Mb3202c (208) |
C4↔3 | Cyp142 | Rv3518c (398) | MT3619 (372) | Mb3547c (193), Mb3548c (205) |
A6↔7 | hypothetical protein | *Rv3773c (194) | MT3882 (194) | Mb3801c (114), Mb3802c (78) |
C2↔ 3 | conserved membrane protein | *Rv3894c (1396) | MT4010 (1396) | Mb3923c (561), b3924c (833) |
II) Muation leading to premature termination (13) | ||||
C7↔8 | Oxido-reductase | *Rv0161 (449) | MT0170 (pt) | Mb0166 (449) |
T5↔4 | umaA1 | *Rv0469 (286) | MT0485 (pt) | Mb0478 (286) |
G4↔3 | Cysteine synthase | *Rv0848 (372) | MT0871 (pt) | Mb0871 (372) |
G3↔ 2 | Membrane transport | *Rv0849 (419) | MT0872 (pt) | Mb0872 (419) |
A2↔3 | Hypothetical protein | - | MT1025.1 (46) | - |
G4↔3 | polyketide synthase pks5 | *Rv1527c (2108) | Prematurely terminated | Mb1554c (2108) |
G3↔2 | Conserved hypothetical | *Rv1533 (375) | Prematurely terminated | 31792719 (375) |
G7↔ 8 | $PE_PGRS(wag22) Antigen | $Rv1759c (914) | $MT1807 (pt) # | $Mb1789c (820), $Mb1790c (94) |
G3↔2 | PE_PGRS | Rv2126c (256) | MT2185 (pt) | Mb2150c (256) |
G2↔3 | Hypothetical protein | Not annotated as orf # | MT2401.2 (69) | Prematurely terminated |
CGCGC2↔3 | Oxidoreductase | *Rv3093c (334) | MT3177 (pt) | Mb3120c (334) |
A3↔2 | *Conserved hypothetical protein | Prematurely terminated | MT3855 (314) * | Not annotated as orf # |
G3↔2 | MycP2, membrane-anchored serine protease | Rv3886c (550) | MT4001 (pt) | Mb3916c (550) |
III) Mutation leading to ORF splitting and 2 nd splitted part is annotated as psuedogene (4) | ||||
C7↔ 8 | Glycolipid sulfotransferase | *Rv1373 (326) | MT1418 (320) | Mb1407 (265) 2 nd part is prematurely terminated |
C6↔ 5 | Hypothetical | *Rv1718 (272) | MT1757 (386) # | Mb1746 (207) Mb1747 (pt) |
G7↔ 8 | GlpK glycerol kinase | *Rv3696c (517) | MT3798 (517) | Mb3721c (pt) Mb3722c (251) |
C2↔ 3 | sigM | *Rv3911 (222) | MT4030 (196) | Mb3941 (196), Mb3942(pt) |
IV) Mutation leading to length variation of orf (43) | ||||
a) Length increase from C-terminal (11) | Â | Â | Â | Â |
T5↔ 4 | CtpI | *Rv0107c(1632) | MT0116 (1625) | Mb0111c (1625) |
G4↔3 | Hypothetical protein | *Rv0607 (128) | MT0636 (147) | Mb0623 (128) |
G3↔2 | lldD1 | *Rv0694 (396) | MT0721 (419) | Mb0713 (396) |
C4↔5 | NusB | *Rv2533c(156) | MT2608 (290) | Mb2562c (156 extra aa) |
G3↔ 2 | transport proteins | *Rv3239c (1048) | MT3337(1065) | Mb3267c (1048) |
GC4↔5 | Hypothetical protein | *Rv0739 (268) | MT0764 (268) | Mb0760 (282) |
A3↔2 | Hypothetical protein | *Rv1046c (174) | MT1075.1 (262) | Mb1075c (197) |
C5↔4 | Conserved hypothetical protein | Rv1760 (502) | MT1809 (531) | Mb1791 (509) |
GC2↔1 | hflX | *Rv2725c (495) | MT2797 (556) | Mb2744c (495) |
T4↔3 | integral membrane | *Rv3162c (145) | MT3251 (145) | Mb3187c (196) |
C3↔2 | $ESAT-6 like protein | $*Rv3890c (95) | $MT4005 (95) | $Mb3919c (124) |
b) Length increase from N-terminal (3) | Â | Â | Â | Â |
G3↔2 | Conserved hypothetical protein | *Rv1246c (97) | MT1284 (143) | Mb1278c (97) |
AC5↔ 6 | lprJ | *Rv1690 (127) S prob 0.939 | MT1729 (127) S prob 0.939 | Mb1716 (139) S prob 0.005 |
G5↔ 4 | Conserve membrane protein | *Rv3693 (440) S prob: 0.994 | MT3795 (475) S prob: 0.0 | Mb3718 (440) |
c) Length decrease from N-terminal (6) | ||||
G2↔3 | PBP-4 (penicilline binding) | *Rv0907(532) | MT0930 (562) | Mb0931 (516) |
G6↔5 | moac2 | *Rv0864 (167) | MT0887 (167) | Mb0888 (142) |
T3↔ 2 | Membrane protein | *Rv1101c (385) s prob 0.708 | MT1133 (385) s prob: 0.708 | Mb1131c (342) s prob 1 |
A6↔5 | aroE | *Rv2552c (269) | MT2629 (269) | Mb2582c (260) |
G2↔ 3 | Memrane protein | Rv2732c (204) | MT2802.1(180) S prob: 0.959. | Mb2791c (204) S prob 0.000 |
G3↔ 2 | Conserve membrane protein | *Rv3885c(537) S prob: 0.993 | MT4000 (422) S prob: 0.0 | Mb3915c (537) |
d) Length decrease from C-terminal (12) | ||||
G6↔5 | membrane protein | *Rv0010c (141) | MT0013 (141) | Mb0010c (111) |
A3↔2 | Conserved hypothetical protein | Rv0025 (120) | MT0028 (90) | Mb0026 (120) |
C3↔ 2 | $NLP/P60 Antigen | $*Rv0024 (281) | $MT0027 (281) | $Mb0024 (277) |
C7↔ 8 | mce2D | *Rv0592 (508) | MT0622 (508) | Mb0607 (478) |
A8↔7 | PPE | *Rv0878c (443) | MT0901 (444) | Mb0902 (438) |
C5↔6 | PPE | *Rv1168c (346) | MT1205 (346) | Mb1201c (180) |
CG5 ↔4 | Secretory protein | *Rv1312 (147) | MT1352 (147) | Mb1344 (144) |
G4↔3 | Hypothetical protein | *Rv1725c (236) | MT1766 (187) | Mb1754c (236) |
TG2↔1 | SseB | Rv2291 (284) | MT2348 (268) | Mb2314 (256) |
G2↔3 | UDP-glucosyltransferases | *Rv2958c (428) | MT3034 (428) | Mb2982c (366) |
G3↔2 | Cyclase | *Rv3377c (501) | MT3487 (501) | Mb3411c (483) |
G2↔3 | Conserve hypothetical | *Rv3836 (137) | MT3944 (133) | Mb3886 (116) |
V) Inframe mutation (11) | ||||
CGGCCC1↔2 | Lipoprotein, s, lipid attach | *Rv0838 (256) | MT0860 (231) | Mb0861 (258) |
GGC5↔4 | PE-PGRS | *Rv0872c (606) | MT0894 (609) | Mb0896c (608) |
CGG5↔4 | PPE | *Rv2356c (615) | MT2425 (615) | Mb2377c (614) |
GCC4↔3 | PE_PGRS | Rv2396 (361) | MT2467.1 (382) | Mb2418 (360) |
TCGACG1↔2 | Hypothetical protein | *Rv1434 (45) | MT1478 (47) | Mb1469 (45) |
G8↔ 11 | membrane protein | *Rv2081c (146) | MT2143 (150) | Mb2107c (147) |
GGC4↔3 | Gdh | *Rv2476c (1624) | MT2551 (1624) | Mb2503c (1623) |
G6↔3 | Transcription regulatory | *Rv2621c (224) | MT2696 (224) | Mb2654c (223) |
GCG5↔4 | PPE | *Rv3159c (590) | MT3247 (603) | Mb3183c (589) |
TGG4↔ 5 | Memrane protein | Rv2799 (209) | MT2867.1 (209) | Mb2822 (210) |
CCG4↔ 3 | moeZ | *Rv3206c (392) | MT3301 (392) | Mb3231c (391) |