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Figure 4 | BMC Genomics

Figure 4

From: In vivo – in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue

Figure 4

Comparison of common significant in vitro and in vivo TCDD elicited time-dependent gene expression changes. A) 285 differentially regulated in vitro genes and 619 differentially regulated in vivo genes were identified, with 67 genes common to both studies. B) The temporal gene expression profiles from both studies were categorized into (I) induced in both, (II) repressed in both, (III) induced in vivo and repressed in vitro, and (IV) repressed in vitro and induced in vivo. C) Hierarchical clustering identified similar classification groups. Clustering across both time and model, separated samples from in vitro and in vivo, with the exception of the early time points from both studies (1 hr in vitro and 2 hr in vivo), which clustered together. * identifies in vitro time points

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