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Table 2 Examples of TCDD-elicited gene expression responses unique to Hepa1c1c7 cells

From: In vivo – in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue

Accession Gene name Gene Symbol Entrez Gene ID Fold changea Time pointsb (hrs)
AA111722 cyclin D1 Ccnd1 12443 -1.7 4, 8, 12, 24c, 48
AA914666 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Cdkn2b 12579 2.4 4c, 8, 48
BC008247 cyclin B2 Ccnb2 12442 -1.8 24c
BG064846 cell division cycle 2 homolog A (S. pombe) Cdc2a 12534 -1.5 12, 24c
AA011839 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) Mcm2 17216 -1.8 8c, 12
BG074721 minichromosome maintenance deficient 7 (S. cerevisiae) Mcm7 17220 -1.7 8, 12c, 24
AA003042 myeloblastosis oncogene-like 2 Mybl2 17865 -2.2 8c, 12, 24
L27122 UDP glucuronosyltransferase 1 family, polypeptide A2 Ugt1a2 22236 2.8 4, 8, 12c, 24, 48
  1. aMaximum absolute fold change determined by microarray analysis
  2. bDifferentially regulated genes with P1(t) > 0.9999 and |fold change| > 1.5
  3. cTime point representing the maximum |fold change|