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Table 1 Substitution rates in constitutive and alternative regions of human-mouse concatenated alignments

From: Fast rate of evolution in alternatively spliced coding regions of mammalian genes

Concatenate type

total alignment length, bp

amino-acid identity

dN

dS

ω

All genes

     

C

2822439

0.891

0.068

0.409

0.166

A

3081642

0.879

0.077

0.410

0.187

AN

2194521

0.880

0.075

0.404

0.186

AI

790026

0.884

0.074

0.421

0.176

AC

97095

0.813

0.133

0.446

0.297

Slow-evolving genes

     

C

897471

0.964

0.020

0.327

0.061

A

920970

0.960

0.023

0.324

0.071

AN

670623

0.961

0.022

0.323

0.068

AI

230754

0.957

0.024

0.327

0.075

AC

19593

0.940

0.036

0.329

0.111

Medium-speed evolving genes

     

C

978984

0.913

0.052

0.422

0.123

A

1092459

0.903

0.059

0.420

0.139

AN

751620

0.903

0.059

0.413

0.142

AI

313896

0.905

0.057

0.434

0.131

AC

26943

0.887

0.073

0.455

0.160

Fast-evolving genes

     

C

945984

0.800

0.135

0.480

0.281

A

1068213

0.785

0.147

0.481

0.306

AN

772278

0.788

0.143

0.474

0.302

AI

245376

0.787

0.148

0.504

0.294

AC

50559

0.724

0.209

0.493

0.425

  1. C – constitutive regions
  2. A – alternative regions
  3. AN – N-terminal alternative regions
  4. AI – internal alternative regions
  5. AC – C-terminal alternative regions
  6. R – the transition to transvertion rate ratio
  7. dN – the nonsynonymous substitution rate
  8. dS – the synonymous substitution rate
  9. ω = dN/dS