Skip to main content

Table 2 Inventory of gene families and their members expressed by PBEC and/or KC.

From: A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes

 

SAGE Tag count#

  

Tissue Preferential Expression values

SAGE Tag Sequence

PBEC CTRL

PBEC IL1β/TNFα

KC CTRL

KC TNFα

Symbol

Description

PBEC CTRL

PBEC IL1β/TNFα

KC CTRL

KC TNFα

Keratins

ACATTTCAAA

0

0

145

127

KRT1

keratin 1

*

*

13,4

12,9

GCCCCTGCTG

96

180

108

115

KRT5

keratin 5

10,2

10,9

11,4

11,6

AAAGCACAAG

267

252

136

235

KRT6A

keratin 6A

12,0

11,9

12,3

12,6

CGAATGTCCT

21

60

84

97

KRT6B

keratin 6B

9,7

10,7

12,2

12,3

GATGTGCACG

12

26

419

514

KRT14

keratin 14

8,6

9,2

13,5

13,5

CAGCTGTCCC

21

25

26

29

KRT16

keratin 16

9,9

10,0

11,1

11,3

CTTCCTTGCC

181

216

431

380

KRT17

keratin 17

9,8

10,0

12,7

12,4

GACATCAAGT

20

48

0

0

KRT19

keratin 19

5,6

6,5

*

*

Small proline-rich proteins

CTGTCACCCT

9

25

126

75

SPRR1A

small proline-rich protein 1A

10,3

11,1

13,8

12,9

CCCTTGAGGA

27

56

264

176

SPRR1B

small proline-rich protein 1B

10,1

10,8

13,5

12,8

ATGATCCCTG

3

12

2

0

SPRR2A

small proline-rich protein 2A

9,1

9,9

10,4

*

TTTCCTGCTC

91

75

0

2

SPRR3

small proline-rich protein 3

9,1

8,9

*

6,3

Calcium binding proteins

GATCTCTTGG

123

170

103

113

S100A2

S100 calcium binding protein A2

8,5

9,0

9,0

9,0

CCCCCTGGAT

61

133

82

32

S100A6

S100 calcium binding protein A6

<4

4,1

<4

<4

TACCTGCAGA

139

214

28

77

S100A8

S100 calcium binding protein A8

5,8

6,4

4,2

5,5

GTGGCCACGG

121

419

77

156

S100A9

S100 calcium binding protein A9

5,6

7,3

6,2

7,2

AGCAGATCAG

114

86

35

70

S100A10

S100 calcium binding protein A10

<4

<4

<4

<4

CAGGCCCCAC

15

29

9

11

S100A11

S100 calcium binding protein A11

<4

<4

<4

<4

TGGGGAGAGG

53

51

30

32

S100A14

S100 calcium binding protein A14

7,7

7,7

8,7

8,7

AGCAGGAGCA

26

54

40

18

S100A16

S100 calcium binding protein A16

4,3

5,3

5,2

4,2

ATCCGCGAGG

0

0

30

29

CALML5

calmodulin-like 5

*

*

12,0

11,6

Annexins

AGAAAGATGT

102

62

7

7

ANXA1

annexin A1

4,5

<4

<4

<4

CTTCCAGCTA

16

43

77

109

ANXA2

annexin A2

<4

<4

4,5

5,0

AAGGGCGCGG

4

8

12

0

ANXA3

annexin A3

<4

4,2

4,7

*

TTGTTATTGC

5

0

2

5

ANXA7

annexin A7

<4

*

<4

<4

CCCTCAGCAC

3

2

0

14

ANXA8

annexin A8

7,9

7,6

*

9,9

Proteinase inhibitors

ATCCTTGCTG

94

85

150

91

CSTA

cystatin A

8,7

8,6

10,6

9,9

ATGAGCTGAC

64

135

37

38

CSTB

cystatin B

5,0

6,1

4,1

4,1

GTGGAGGGCA

2

2

12

27

CST6

cystatin E/M

4,7

4,7

6,6

7,3

CATTGTAAAT

16

12

26

14

SERPINB5

serine proteinase inhibitor, member 5

9,6

9,4

11,3

10,4

TTGAATCCCC

30

80

56

50

PI3

elafin, protease inhibitor 3, (SKALP)

8,0

9,0

9,9

9,6

TGTGGGAAAT

18

40

101

124

SLPI

secretory leukocyte protease inhibitor

5,3

6,3

7,7

8,0

  1. Expression of these gene families was observed in both PBEC and KC, whereas these cells differ in the expression pattern of the individual family members. From left to right the SAGE tag sequence, SAGE tag counts as observed in the SAGE libraries (unstimulated PBEC, IL1β/TNFα-stimulated PBEC, unstimulated KC and TNFα-stimulated KC), HUGO approved gene symbol and gene description and the calculated Tissue Preferential Expression Values (unstimulated PBEC, IL1β/TNFα-stimulated PBEC, unstimulated KC and TNFα-stimulated KC) are indicated. No TPE values could be calculated for those tags that were absent in one or more libraries and are indicated by (*) in the table. #A selection of these SAGE tag counts were represented in previously published tables [11,12]; all tag counts are available online through the NCBI Gene Expression Omnibus (GEO) website [37] with GEO accessions as listed in the methods.
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us