Table 2 Chromosomal regions of differential gene expression in cancer. (A) Number of hits, i.e. number of genes with differential expression per chromosome, is depicted. 'Up' and 'down' mean chromosomal regions with increased and decreased tumor expression, respectively. '%' represents the percentage of candidate genes against the total number of genes present on the chromosome. (B) Chromosomal regions found to be associated with at least 5 hits in the digital subtraction analysis are shown ('banding'). '%' represents the percentage of hits for a particular chromosomal banding against the total number of genes present in the same banding. Chromosomal bandings marked in bold correspond to previously identified regions associated with either tumor amplicon ('Up' column) or deleted ('Down' column) regions in tumors.

1

33

1.02

54

1.68

87

2.70

1q21.3

1q32.1

3.12

3.20

2

11

0.75

28

1.90

39

2.65

2p11.2

2p13.3

2q35

6.66

9.26

4.55

3

11

0.55

58

2.89

69

3.43

3p21.31

4.03

3p21.31

3.14

4

38

2.26

46

2.73

84

4.99

4q13.3

9.37

5

4

0.67

8

1.35

12

2.02

5q33.1

6.58

6

14

1.22

36

3.15

50

4.37

6p21.31

6.33

7

11

1.05

19

1.81

30

2.86

7q21. 3

7q22.1

8.93

3.32

8

18

1.25

30

2.08

48

3.34

9

31

1.69

39

2.13

70

3.82

9q34.11

9q34.3

3.60

3.60

10

5

1.05

10

2.10

15

3.15

11

30

1.32

46

2.03

76

3.36

11p15.1

11p15.4

11p15.5

11q12.2

7.81

2.56

5.88

7.81

12

25

1.14

61

2.78

86

3.91

12q13.13

12q13.3

4.80

10.12

12q13.13

7.20

13

19

1.76

21

1.94

40

3.70

14

5

1.27

8

2.03

13

3.29

14q11.2

2.59

14q11.2

14q32.33

2.59

8.89

15

7

0.84

16

1.93

23

2.77

16

19

1.08

40

2.28

59

3.36

16p11.2

3.10

16p11.2

16q12.2

3.10

9.80

17

9

0.74

38

3.14

47

3.88

17q21.2

17q25.3

5.71

2.81

17q21.2

17q23.3

5.00

8.06

18

12

0.86

31

2.22

43

3.08

19

14

0.80

29

1.65

43

2.44

19p13.3

2.43

19p13.11

19q13. 2

19q13.31

19q13.33

2.15

3.69

7.04

3.14

20

10

0.56

38

2.13

48

2.69

20q13.12

2.92

21

8

0.70

25

2.18

33

2.87

21q22.3

3.12

21q22.3

3.75

22

17

1.20

31

2.19

48

3.40

X

21

1.59

31

2.34

52

3.93

Xq28

4.76

Y

1

0.64

1

0.64

2

1.27