Figure 5

Alignment of human, potato and flea proteins of the apyrase/CD39 family. Human sequences are identified by HS_#_???? where # is the enzyme number and ???? refers to the NCBI gi accession number. The potato sequence is identified by ST_1 followed by the NCBI accession number. The flea sequence is indicated by the prefix XC. The boxes mark the 4 conserved domains identified by Wang et al [60]. The lines above the alignments indicate the regions of hydrophobic helices in the amino and terminal regions, the last of which is lacking in the four bottom sequences, representing the 2 human secreted enzymes, plus the potato and the flea enzymes.