Skip to main content

Table 1 Genes of the M. smegmatis GPL locus and their orthologs in M. abscessus and M. chelonae.

From: Genomics of glycopeptidolipid biosynthesis in Mycobacterium abscessus and M. chelonae

M. smegmatis

M. abscessus

M. chelonae

Gene

Gene n°

Proposed function(a)

Gene n°

%(b)

Gene n°

%(b)

mmpS4

MSMEG0373

Membrane associated. Interaction with Pks, °

ma4117c

78

mc1618

74

mmpL4a

MSMEG0374

Membrane associated. Interaction with Pks, °

ma 4116c

78

mc1619

77

mmpL4b

MSMEG0375

Membrane associated. Interaction with Pks, °

ma4115c

76

mc1620

75

Rv1174

MSMEG0376

None

ma4114

48

mc1621c

48

rmlA

MSMEG0377

Alpha-D-hexose-1-phosphate-thymidylyl-transferase (EC 2.7.7.24), °

ma4113

85

mc1622c

85

gtf3

MSMEG0378

D-Rhamnose rhamnosyltransferase, +

ma4112c

49

mc1623

71

rmlB

MSMEG0379

UDP-hexose 4-epimerase, °

ma4111c

77

mc1624

78

rmt2

MSMEG0380

Rhamnose 2-O-methyltransferase, +

ma4109c

72

mc1626

70

rmt4

MSMEG0381

Rhamnose 4-O-methyltransferase, +

ma4108c

83

mc1627

83

gtf1

MSMEG0382

D-allo-threonine 6-deoxytalosyltransferase, +

ma4107c

76

mc1628

77

atf

MSMEG0383

Integral membrane protein. 6-deoxytalose 3,4-O-acetyltransferase, +

ma4106c(c)

72

mc1629(c)

76

   

ma4110c(d)

59

mc1625(d)

60

rmt3

MSMEG0384

Rhamnose 3-O-methyltransferase, +

ma4105c

81

mc1630

82

gtf

MSMEG0385

L-alaninol rhamnosyltransferase, +

ma4104

67

mc1631c

72

fmt

MSMEG0386

Fatty acid O-methyltransferase, +

ma4103c

67

mc1632

62

mbtH

MSMEG0387

None

ma4100c

89

mc1635

89

mps1

MSMEG0390

Non-ribosomal protein synthase. Synthesis of the dipeptide, +°

ma4099c

70

mc1636

70

mps2

MSMEG0392

Non-ribosomal protein synthase. Synthesis of the amino acid alcohol, +°

ma4098c

71

mc1637

72

gap

MSMEG0393

Integral membrane protein. Required for GPL export, +

ma4097c

58

mc1638

55

sap

MSMEG0394

Sigma-associated protein

ma4454c

30

mc1299

30

ecf

MSMEG0395

Sigma factor of the ECF family. Required for regulation

ma4459c

46

mc1294

47

fadE5

MSMEG0396

Fatty acid desaturase, °

ma4437

78

mc1318c

78

Rv0926

MSMEG0397

None

ma4633

36

mc1136c

36

pks

MSMEG0398

Fatty acid synthesis and activation, +°

ma0939

79

mc0819

79

papA3

MSMEG0399

Transfer of the Pks-bound fatty acid to the pseudotetrapeptide, °

ma0938c

77

mc0818c

77

mmpL10

MSMEG0400

Membrane associated. Interaction with Pks, °

ma0937c

75

mc0817c

74

fadD23

MSMEG0401

Long chain fatty acyl-AMP ligase, °

ma0935c

73

mc0815c

74

pe

MSMEG0402

None

ma0936c

64

mc0816c

66

gap-like

MSMEG0403

Integral membrane protein. Role in the transport of GPLs, °

ma0934

55

mc0814

55

  1. (a) +, experimentally validated function; °, in silico predicted function.
  2. (b) Percentage of identity between M. abscessus or M. chelonae genes and M. smegmatis genes.
  3. (c) atf1 (see text and legend to Fig. 3).
  4. (d) atf2 (see text and legend to Fig. 3).