Figure 3

a) Sequence-structure alignment ORFan L529 and yeast translation initiation factor (PDB code: 1ap8). The eight conserved tryptophans of 1ap8 are numbered as 1–8. The conserved terminal tryptophans (Trp-1 & Trp-8) are shown in yellow boxes. The consensus motif (S/T)VxxxFW is highlighted in green color. b) Ribbon diagram of predicted model of ORFan L529. The model was built from FFAS03 [55] and refined using Nest [53]. The model shows curved antiparallel β-sheet with two long helices present on one side. The conserved tryptophan residues (Trp25 and Trp124) required for cap recognition are shown in ball-and-sticks.