Table 1 Highly confident 3D structural and functional predictions for 6 Mimivirus ORFans.
From: Structural and functional insights into Mimivirus ORFans
ORFan | 3D-Jury score | 3D-Jury First Hit | Predicted Fold | Predicted Function | Function specific Sequence Features | |
|---|---|---|---|---|---|---|
| Â | Â | PDB code | Name | Â | Â | Â |
R843 | 119.8 | 1fj2A | Human acyl protein Thioesterase 1 | α/β-Hydrolase | Carboxylesterase/Thioesterase | Catalytic triad, 'HG' oxyanion motif and PROSITE signature pattern of carboxylesterase conserved. |
L374 | 108.4 | 1q7tA | Metal-Dependent Deacetylase | LmbE-like | Metal-Dependent Deacetylase | Deacetyl 'AHPDDE' sequence motif and metal binding residues conserved. |
L834 | 82.1 | 1r28A | B-cell Lymphoma 6 (bcl6) BTB domain | POZ domain | BTB domain | Residues Asp and Arg/Lys in the charged pocket of BTB domain, important for transcriptional repression conserved. |
R277 | 63.9 | 1yj5A | Mammalian Polynucleotide Kinase | P-loop containing nucleoside triphosphate hydrolases | P-loop kinases | P-loop (walker-A and walker-B motifs) and arginine motif conserved. |
L759 | 70.7 | 1ewnA | Human AAG DNA repair Glycosylase | FMT C-terminal domain-like | 3-methyladenine DNA glycosylase | Active site residues Glu, Tyr, His, Tyr and Arg conserved. |
L529 | 62.1 | 1ap8 | Translation Initiation factor eIF4e | Translation Initiation factor eIF4e | Translation Initiation factor eIF4e | Trp residues important for CAP binding conserved. |