Figure 4

Variation in the modeling performance of cell lines to cervical cancer at a pathway-specific level. A: The "Regulation of Apoptosis" pathway (GO:42981) revealed that better global model to cervical cancer (primary, C4-I, and C4-II, discussed above) were not necessarily better models of specific pathways. In this pathway, the best models among those we tested were the primary cell line and HeLa cultured in an organotypic environment. Eight genes from the sub-pathway "Anti-Apoptosis" (GO:6916) were primarily responsible for lowering the correlation of the C4-II cell line. An average of 71 ± 5 genes were used to calculate the correlation for each cell line. B: In the example of the "G-protein Signaling" pathway (GO:7186), HeLa cultured as a monolayer in ATCC recommended media had an anti-correlation (-0.3) to cervical cancer. Fourteen out of 71 genes were primarily responsible for the negative correlation to cervical cancer. An average of 72 ± 7 genes were used to calculate the correlation for each cell line.