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Table 1 The top 16 up-and down-regulated genes between normal cervix and cervical cancer.

From: Quantitative gene expression assessment identifies appropriate cell line models for individual cervical cancer pathways

Clone ID

Unigene ID

Gene Name

Gene Description

Fold Change

810131

Hs.2785

KRT19

keratin 19**

21.2

135975

Hs.642947

DSP

desmoplakin*

14.8

2497698

Hs.156346

TOP2A

topoisomerase (DNA) II alpha*

13

2541366

Hs.234642

AQP3

aquaporin 3**

11.8

177074

Hs.591205

ZIC2

Zic family member 2

11.8

2444518

Hs.465506

PPAP2C

phosphatidic acid phosphatase type 2C

11.1

511428

Hs.301350

FXYD3

FXYD domain containing ion transport regulator 3

10

951241

Hs.615092

NUSAP1

nucleolar and spindle associated protein 1

9.5

712505

Hs.334562

CDC2

cell division cycle 2, G1 to S and G2 to M**

9.4

781089

Hs.350966

PTTG1

pituitary tumor-transforming 1*

9.3

25389

Hs.473721

SLC2A1

solute carrier family 2*

8.9

296155

Hs.434886

CDCA5

cell division cycle associated 5**

7.1

253009

Hs.556259

PRO1073

PRO1073 protein

6.6

378365

Hs.520421

PIGPC1

p53-induced protein PIGPC1

6

769921

Hs.93002

UBE2C

ubiquitin-conjugating enzyme E2C*

5.9

685026

Hs.481208

AMMECR1

Alport syndrome, midface hypoplasia

5.5

344139

Hs.104672

DOC1

downregulated in ovarian cancer 1

-6.7

813823

Hs.406475

LUM

lumican

-6.8

1607286

Hs.8867

CYR61

cysteine-rich, angiogenic inducer

-6.9

32609

Hs.213861

LAMA4

laminin, alpha 4**

-7

855557

Hs.472831

PKIG

protein kinase (cAMP-dependent) inhibitor gamma

-7

366100

Hs.189445

MATN2

matrilin 2

-7.2

2495781

Hs.516578

TFPI

tissue factor pathway inhibitor**

-7.3

878182

Hs.212838

A2M

alpha-2-macroglobulin

-8

300015

Hs.597358

LEPR

leptin receptor

-8.7

809719

Hs.477128

URB

steroid sensitive gene 1

-9.2

186757

Hs.591469

DDR2

discoidin domain receptor family

-9.8

49354

Hs.620557

ANK2

ankyrin 2, neuronal

-10.4

1534435

Hs.104839

TIMP2

tissue inhibitor of metalloproteinase 2

-10.7

839623

Hs.69855

NRAS

neuroblastoma RAS viral (v-ras) oncogene

-12.6

1636447

Hs.83381

GNG11

guanine nucleotide binding protein**

-15.8

813266

Hs.598421

FHL1

four and a half LIM domains 1

-21.6

  1. A subset of the 140 genes differentially regulated between normal cervix and invasive cervical cancer, as shown in Additional file 1. Genes marked with an (*) were also reported in the cervical cancer literature; genes marked with an (**) were homologs that were reported in the previous cervical cancer literature.