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Table 1 The top 16 up-and down-regulated genes between normal cervix and cervical cancer.

From: Quantitative gene expression assessment identifies appropriate cell line models for individual cervical cancer pathways

Clone ID Unigene ID Gene Name Gene Description Fold Change
810131 Hs.2785 KRT19 keratin 19** 21.2
135975 Hs.642947 DSP desmoplakin* 14.8
2497698 Hs.156346 TOP2A topoisomerase (DNA) II alpha* 13
2541366 Hs.234642 AQP3 aquaporin 3** 11.8
177074 Hs.591205 ZIC2 Zic family member 2 11.8
2444518 Hs.465506 PPAP2C phosphatidic acid phosphatase type 2C 11.1
511428 Hs.301350 FXYD3 FXYD domain containing ion transport regulator 3 10
951241 Hs.615092 NUSAP1 nucleolar and spindle associated protein 1 9.5
712505 Hs.334562 CDC2 cell division cycle 2, G1 to S and G2 to M** 9.4
781089 Hs.350966 PTTG1 pituitary tumor-transforming 1* 9.3
25389 Hs.473721 SLC2A1 solute carrier family 2* 8.9
296155 Hs.434886 CDCA5 cell division cycle associated 5** 7.1
253009 Hs.556259 PRO1073 PRO1073 protein 6.6
378365 Hs.520421 PIGPC1 p53-induced protein PIGPC1 6
769921 Hs.93002 UBE2C ubiquitin-conjugating enzyme E2C* 5.9
685026 Hs.481208 AMMECR1 Alport syndrome, midface hypoplasia 5.5
344139 Hs.104672 DOC1 downregulated in ovarian cancer 1 -6.7
813823 Hs.406475 LUM lumican -6.8
1607286 Hs.8867 CYR61 cysteine-rich, angiogenic inducer -6.9
32609 Hs.213861 LAMA4 laminin, alpha 4** -7
855557 Hs.472831 PKIG protein kinase (cAMP-dependent) inhibitor gamma -7
366100 Hs.189445 MATN2 matrilin 2 -7.2
2495781 Hs.516578 TFPI tissue factor pathway inhibitor** -7.3
878182 Hs.212838 A2M alpha-2-macroglobulin -8
300015 Hs.597358 LEPR leptin receptor -8.7
809719 Hs.477128 URB steroid sensitive gene 1 -9.2
186757 Hs.591469 DDR2 discoidin domain receptor family -9.8
49354 Hs.620557 ANK2 ankyrin 2, neuronal -10.4
1534435 Hs.104839 TIMP2 tissue inhibitor of metalloproteinase 2 -10.7
839623 Hs.69855 NRAS neuroblastoma RAS viral (v-ras) oncogene -12.6
1636447 Hs.83381 GNG11 guanine nucleotide binding protein** -15.8
813266 Hs.598421 FHL1 four and a half LIM domains 1 -21.6
  1. A subset of the 140 genes differentially regulated between normal cervix and invasive cervical cancer, as shown in Additional file 1. Genes marked with an (*) were also reported in the cervical cancer literature; genes marked with an (**) were homologs that were reported in the previous cervical cancer literature.