Table 1 Irregular LRR motifs observed in the known structures of LRR-containing proteins
From: Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors
Proteina | Nb | Irregular LRRs | PDB | ||
|---|---|---|---|---|---|
| Â | Â | Position | Amino acid sequencec | Â | Â |
| Â | Â | Â | LxxLxLxxNxL | Â | Â |
TLR3 | 25 | LRR1 | H EVADCSHL KL | TQVPDDLPTN | 1ZIW |
| Â | Â | LRR9 | LFGLFLNNV QL | GPSLTEKLCLELANTS | /2A0Z |
| Â | Â | LRR13 | VRYLNLKRSFT | KQSISLASLPKIDDFSFQWLKC | Â |
| Â | Â | LRR15 | LKYLSLSNSFT | SLRTLTNETFVSLAHSP | Â |
| Â | Â | LRR18 | IFEIYLSYNKY | LQLTRNSFALVPS | Â |
| Â | Â | LRR19 | LQRLMLRRV AL | KNVDSSPSPFQPLRN | Â |
CD14 | 11 | LRR1 | AADVELYGG GR | SLEYLLKRVDTEADLGQFTDIIKSLS | 1WWL |
| Â | Â | LRR2 | LKRLTVRAA RI | PSRILFGALRVLGISG | Â |
| Â | Â | LRR3 | LQELTLENL EV | TGTAPPPLLEATGPD | Â |
| Â | Â | LRR4 | LNILNLRNV SW | ATRDAWLAELQQWLKPG | Â |
| Â | Â | LRR5 | LKVLSIAQA HS | LNFSCEQVRVFPA | Â |
| Â | Â | LRR7 | LQVLALRNA GM | ETPSGVCSALAAARVQ | Â |
Slit | 6 | LRR1 | G TTVDCTGR GL | KEIPRDIPLH | 1W8A |
Lingo-1 | 14 | LRR8 | LIVLRLRHL NI | NAIRDYSFKRLYR | 2ID5 |
| Â | Â | LRR9 | LKVLEISHW PY | LDTMTPNCLYGLN | Â |
Decorin | 12 | LRR1 | LRVVQCSDL GL | EKVPKDLPPD | 1XCD |
Biglycan | 12 | LRR1 | LRVVQCSDL GL | KAVPKEISPD | 2FT3 |
FSHr | 10 | LRR6 | LQKVLLDIQ DN | INIHTIERNSFVGLSFE | 1XWD |
| Â | Â | LRR7 | S VILWLNKNGI | QEIHNCAFNGTQ | Â |
| Â | Â | LRR9 | P VILDISRTRI | HSLPSYGLEN | Â |
Inl-A | 16 | LRR1 | VTTLQADRL GI | KSIDGLEYLNN | 1O6V |
Inl-C | 7 | LRR1 | VQNFNG DNSNI | QSLAGMQFFTN | 1XEU |
| Â | Â | LRR7 | VNWIDLTGQ KC | VNEPVKYQPEL | Â |
U2snRNPA' | 5 | LRR1 | DRELDLRGY KI | PVIRNLGATLDQ | 1A9N |
RabGGTα | 5 | LRR1 | VRVLHLAHK DL | TVLCHLEQLLL | 1DCE |
DLC1 | 6 | LRR1 | K VELHG MIP PI | EKMDATLSTLKA | 1DS9 |
TAP | 4 | LRR1 | Q QALDLKGL RS | DPDLVAQNIDVVLNRRSCMAATLRII | 1FT8 |
| Â | Â | Â | Â | EENIPE | Â |
PGIP | 10 | LRR1 | VNNLDLSGL NL | PKPYPIPSSLANLPYL | 1OGQ |
YoPM | 16 | LRR1 | AHELELNNL GL | SSLPELPPH | 1G9U |
| Â | Â | LRR16 | VEDLRMNSE RV | DPYEFAHETTDKLEDDVFE | Â |
hRI | 16 | LRR15 | LEQLVLYDI YW | SEEMEDRLQALEKDKP | 1Z7X |
pRI | 17 | LRR1 | W_ NLDIHCE QL | SDARWTELPLQQ | 2BNH |
RanGAP | 10 | LRR2 | LEIAEFSDI FT | GRVKDEIPEALRLLLQALLKCPK | 1YRG |
cTmod | 5 | LRR1 | LEEVNLNNI MN | IPVPTLKACAEALKTNTY | 1IO0 |
| Â | Â | LRR2 | VKKFSIVGTRS | NDPVAFALAEMLKVNNT | Â |
| Â | Â | LRR4 | LIELRIDNQ SQ | PLGNNVEMEIANMLEKNTT | Â |
| Â | Â | LRR5 | LLKFGY HFTQQ | PRLRASNAMMNNNDLVRK | Â |
ceTmod | 5 | LRR1 | LKEVNINNM KR | VSKERIRSLIEAACNSKH | 1PGV |
| Â | Â | LRR4 | IVEFKADNQ RQ | SVLGNQVEMDMMMAIEENES | Â |
| Â | Â | LRR5 | LLRVGISFA SM | EARHRVSEALERNYERVRL | Â |
Skp2 | 11 | LRR1 | WQTLDLTGK NL | HPDVTGRLLSQG | 1FQV |
| Â | Â | LRR4 | LQNLSLWFL RL | SDPIVNTLAKNSN | /2ASS |
| Â | Â | LRR7 | ITQLNLSGY RK | NLQKSDLSTLVRRCPN | Â |
| Â | Â | LRR10 | LKTLQVFGI VP | DGTLQLLKEA | Â |