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Table 1 Irregular LRR motifs observed in the known structures of LRR-containing proteins

From: Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors

Proteina Nb Irregular LRRs PDB
   Position Amino acid sequencec   
    LxxLxLxxNxL   
TLR3 25 LRR1 H EVADCSHL KL TQVPDDLPTN 1ZIW
   LRR9 LFGLFLNNV QL GPSLTEKLCLELANTS /2A0Z
   LRR13 VRYLNLKRSFT KQSISLASLPKIDDFSFQWLKC  
   LRR15 LKYLSLSNSFT SLRTLTNETFVSLAHSP  
   LRR18 IFEIYLSYNKY LQLTRNSFALVPS  
   LRR19 LQRLMLRRV AL KNVDSSPSPFQPLRN  
CD14 11 LRR1 AADVELYGG GR SLEYLLKRVDTEADLGQFTDIIKSLS 1WWL
   LRR2 LKRLTVRAA RI PSRILFGALRVLGISG  
   LRR3 LQELTLENL EV TGTAPPPLLEATGPD  
   LRR4 LNILNLRNV SW ATRDAWLAELQQWLKPG  
   LRR5 LKVLSIAQA HS LNFSCEQVRVFPA  
   LRR7 LQVLALRNA GM ETPSGVCSALAAARVQ  
Slit 6 LRR1 G TTVDCTGR GL KEIPRDIPLH 1W8A
Lingo-1 14 LRR8 LIVLRLRHL NI NAIRDYSFKRLYR 2ID5
   LRR9 LKVLEISHW PY LDTMTPNCLYGLN  
Decorin 12 LRR1 LRVVQCSDL GL EKVPKDLPPD 1XCD
Biglycan 12 LRR1 LRVVQCSDL GL KAVPKEISPD 2FT3
FSHr 10 LRR6 LQKVLLDIQ DN INIHTIERNSFVGLSFE 1XWD
   LRR7 S VILWLNKNGI QEIHNCAFNGTQ  
   LRR9 P VILDISRTRI HSLPSYGLEN  
Inl-A 16 LRR1 VTTLQADRL GI KSIDGLEYLNN 1O6V
Inl-C 7 LRR1 VQNFNG DNSNI QSLAGMQFFTN 1XEU
   LRR7 VNWIDLTGQ KC VNEPVKYQPEL  
U2snRNPA' 5 LRR1 DRELDLRGY KI PVIRNLGATLDQ 1A9N
RabGGTα 5 LRR1 VRVLHLAHK DL TVLCHLEQLLL 1DCE
DLC1 6 LRR1 K VELHG MIP PI EKMDATLSTLKA 1DS9
TAP 4 LRR1 Q QALDLKGL RS DPDLVAQNIDVVLNRRSCMAATLRII 1FT8
     EENIPE  
PGIP 10 LRR1 VNNLDLSGL NL PKPYPIPSSLANLPYL 1OGQ
YoPM 16 LRR1 AHELELNNL GL SSLPELPPH 1G9U
   LRR16 VEDLRMNSE RV DPYEFAHETTDKLEDDVFE  
hRI 16 LRR15 LEQLVLYDI YW SEEMEDRLQALEKDKP 1Z7X
pRI 17 LRR1 W_ NLDIHCE QL SDARWTELPLQQ 2BNH
RanGAP 10 LRR2 LEIAEFSDI FT GRVKDEIPEALRLLLQALLKCPK 1YRG
cTmod 5 LRR1 LEEVNLNNI MN IPVPTLKACAEALKTNTY 1IO0
   LRR2 VKKFSIVGTRS NDPVAFALAEMLKVNNT  
   LRR4 LIELRIDNQ SQ PLGNNVEMEIANMLEKNTT  
   LRR5 LLKFGY HFTQQ PRLRASNAMMNNNDLVRK  
ceTmod 5 LRR1 LKEVNINNM KR VSKERIRSLIEAACNSKH 1PGV
   LRR4 IVEFKADNQ RQ SVLGNQVEMDMMMAIEENES  
   LRR5 LLRVGISFA SM EARHRVSEALERNYERVRL  
Skp2 11 LRR1 WQTLDLTGK NL HPDVTGRLLSQG 1FQV
   LRR4 LQNLSLWFL RL SDPIVNTLAKNSN /2ASS
   LRR7 ITQLNLSGY RK NLQKSDLSTLVRRCPN  
   LRR10 LKTLQVFGI VP DGTLQLLKEA  
  1. aFSHr, follicle-stimulating hormone receptor; Inl-A, internalin A; Inl -C, internalin C; U2snRNPA', spliceosomal U2A' protein; RabGGTα, rab geranylgeranyltransferase α-subunit; DLC-1, Chlamydomonas outer arm dynein light chain 1; TAP, mRNA export factor; PGIP, polygalacturonase-inhibiting protein; RI, ribonuclease inhibitor, RanGAP, GTPase-activating protein; Tmod, tropomodulin; Skp2, S-phase kinase-associated protein 2; h, human, p, pig; ce, Caenorhabditis elegans: b N; the repeat number of LRRs identified in individual known LRR structures.c HCS, highly conserved segment of LRR; VS, variable segment of LRR. Residues in boldface cause irregular motif.