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Table 2 The repeat number of LRRs and its flanking cysteine clusters in vertebrate TLRs

From: Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors

Famliya Protein Speciesb NLc LRRNTd LRRCTd NBe
TLR1 TLR1 h, m, p 20(8–9) No CxCx 25 Cx 20 C 1
  " t 21 CxCx 29 Cx 20 C CxCx 29 Cx 20 C 1
  TLR2 h, m, p, b, r, d, ra, g, ho, dwb, ha, cm, n 20(14–18) Cx 5 C CxCx 24 Cx 20 C 1
  TLR2.1 c 20(13) Cx 2 Cx 5 CxC CxCx 24 Cx 20 C 1
  TLR2.2 c 20(13) Cx 2 Cx 5 CxC CxCx 24 Cx 20 C 1
  TLR2 t 20 Cx 2 Cx 5 CxC CxCx 25 Cx 20 C 1
  TLR2 jf 19 Cx 2 Cx 5 CxC CxCx 25 Cx 20 C 1
  TLR2 z 21 Cx 3 CxCx 5 CxC CxCx 24 Cx 20 C 1
  TLR6 h, m, r, p, b 20(13–14) No CxCx 25 Cx 20 C 1
  TLR10 h, p 20(12) No CxCx 25 Cx 20 C 1
  TLR14 t, z 21 Cx 10 C CxCx 25 Cx 20 C 1
TLR3 TLR3 h, m, b, r, bu, rm, z 25(22–24) Cx 8 C CxCx 25 Cx 18 C 1
  " t 25 Cx 8 C CxCx 26 Cx 18 C 1
  " jf 27 Cx 8 C CxCx 24 Cx 18 C 1
  TLR as 27 Cx 15 C CxCx 24 Cx 18 C 1
  " rt 27 Cx 15 C CxCx 24 Cx 18 C 1
  " go 27 Cx 14 C CxCx 24 Cx 18 C 1
  TLRII rt 27 Cx 6 Cx 17 C CxCx 24 Cx 18 C 1
TLR4 TLR4 h, lg, pc, ob, or 23(21) Cx 10 C CxCx 23 Cx 17 C 1
  " m, p, r, ch, ho, b, ab, n, 23(18–19) Cx 10 C CxCx 23 Cx 18 C 1
  " ha, ra 23 Cx 10 C CxCx 23 Cx 15 C 1
  TLR4b z 23 Cx 10 C CxCx 23 Cx 18 C 1
  TLR4 h [Q5VZ17] 16 Cx 10 C CxCx 23 Cx 18 C 1
  " d 16 No CxCx 23 C 1
TLR5 TLR5 h, m, r, p, b, jhm 22(15–16) Cx 11 C CxCx 24 Cx 18 C 1
  " t 22 Cx 10 C CxCx 24 Cx 22 C 1
  " rt 22 Cx 8 C Cx 27 C 1
  TLRS5 t 23 Cx 8 C Cx 26 C 1
TLR11 TLR11 M 25(11) Cx 17 Cx 11 Cx 20 C CxCx 24 Cx 19 C 1
  TLR12 m 24(17) Cx 17 Cx 11 Cx 20 C CxCx 24 Cx 19 C 1
  TLR13 m 27(21) Cx 11 C CxCx 24 Cx 16 C 1
  TLR21 t 27 Cx 10 C CxCx 24 Cx 15 C 1
  TLR22 t 27 Cx 8 C CxCx 24 Cx 18 C 1
  TLR23 t 27 Cx 14 C CxCx 24 Cx 18 C 1
TLR7 TLR7 H, m, d 27(27–28) Cx 14 C CxCx 24 Cx 18 C 2
  " t 27 Cx 12 C CxCx 24 Cx 18 C 2
  TLR8 h, m, p 27(24–26) Cx 12 C CxCx 24 Cx 18 C 2
  " t 27 Cx 13 C CxCx 24 Cx 18 C 2
  TLR9 h, m, p, b, d, ca, ho, s, mnm 27(26) Cx 9 C CxCx 23 Cx 18 C 2
  " t, jf, gsb 27 Cx 10 C CxCx 23 Cx 18 C 2
  TLR gp 28, 26 ? CxCx 24 Cx 18 C 2
Others TLRa Jl 21 Cx 8 C CxCx 22 C 12 C 1
  TLRb jl 21 Cx 8 C CxCx 22 Cx 20 C 1
  TLR15 c 21 No CxCx 24 Cx 20 C 2
  1. aThe six families and others. bAbbreviations: ab, American bison; as, Atlantic salmon; b, bovine; c, chicken; ca, cat; ch, Chinese hamster; cm, Cynomolgus monkey; d, dog; dwd, Domestic water buffalo; g, goat; go, Goldfish; gp, green puffer; gsb, Gilthead sea bream; h, human; ha, hamster; ho, horse; jf, Japanese flounder; jhm, Japanese house mouse; jl, Japanese lamprey; lg, lowland gorilla; m, mouse; mnm, Ma's night monkey; n, Nilgai; ob, Olive baboon; or, Orangutan; p, pig; pc, Pygmy chimpanzee; r, rat; ra, rabbit; rm, Rhesus macaque; rt, Rainbow trout; s, sheep; t, Takifugu rubripes; z, Zebrafish. cNL; the repeat number of LRRs. The number of parenthesis is NL reported in the Interpro datbase.d LRRNT, the cysteine clusters on the N-terminal side of LRRs; LRRCT, the cysteine clusters on the C-terminal side of LRRs. eNB; the number of horseshoe domains of the LRRs.