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Table 2 The repeat number of LRRs and its flanking cysteine clusters in vertebrate TLRs

From: Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors

Famliya

Protein

Speciesb

NLc

LRRNTd

LRRCTd

NBe

TLR1

TLR1

h, m, p

20(8–9)

No

CxCx 25 Cx 20 C

1

 

"

t

21

CxCx 29 Cx 20 C

CxCx 29 Cx 20 C

1

 

TLR2

h, m, p, b, r, d, ra, g, ho, dwb, ha, cm, n

20(14–18)

Cx 5 C

CxCx 24 Cx 20 C

1

 

TLR2.1

c

20(13)

Cx 2 Cx 5 CxC

CxCx 24 Cx 20 C

1

 

TLR2.2

c

20(13)

Cx 2 Cx 5 CxC

CxCx 24 Cx 20 C

1

 

TLR2

t

20

Cx 2 Cx 5 CxC

CxCx 25 Cx 20 C

1

 

TLR2

jf

19

Cx 2 Cx 5 CxC

CxCx 25 Cx 20 C

1

 

TLR2

z

21

Cx 3 CxCx 5 CxC

CxCx 24 Cx 20 C

1

 

TLR6

h, m, r, p, b

20(13–14)

No

CxCx 25 Cx 20 C

1

 

TLR10

h, p

20(12)

No

CxCx 25 Cx 20 C

1

 

TLR14

t, z

21

Cx 10 C

CxCx 25 Cx 20 C

1

TLR3

TLR3

h, m, b, r, bu, rm, z

25(22–24)

Cx 8 C

CxCx 25 Cx 18 C

1

 

"

t

25

Cx 8 C

CxCx 26 Cx 18 C

1

 

"

jf

27

Cx 8 C

CxCx 24 Cx 18 C

1

 

TLR

as

27

Cx 15 C

CxCx 24 Cx 18 C

1

 

"

rt

27

Cx 15 C

CxCx 24 Cx 18 C

1

 

"

go

27

Cx 14 C

CxCx 24 Cx 18 C

1

 

TLRII

rt

27

Cx 6 Cx 17 C

CxCx 24 Cx 18 C

1

TLR4

TLR4

h, lg, pc, ob, or

23(21)

Cx 10 C

CxCx 23 Cx 17 C

1

 

"

m, p, r, ch, ho, b, ab, n,

23(18–19)

Cx 10 C

CxCx 23 Cx 18 C

1

 

"

ha, ra

23

Cx 10 C

CxCx 23 Cx 15 C

1

 

TLR4b

z

23

Cx 10 C

CxCx 23 Cx 18 C

1

 

TLR4

h [Q5VZ17]

16

Cx 10 C

CxCx 23 Cx 18 C

1

 

"

d

16

No

CxCx 23 C

1

TLR5

TLR5

h, m, r, p, b, jhm

22(15–16)

Cx 11 C

CxCx 24 Cx 18 C

1

 

"

t

22

Cx 10 C

CxCx 24 Cx 22 C

1

 

"

rt

22

Cx 8 C

Cx 27 C

1

 

TLRS5

t

23

Cx 8 C

Cx 26 C

1

TLR11

TLR11

M

25(11)

Cx 17 Cx 11 Cx 20 C

CxCx 24 Cx 19 C

1

 

TLR12

m

24(17)

Cx 17 Cx 11 Cx 20 C

CxCx 24 Cx 19 C

1

 

TLR13

m

27(21)

Cx 11 C

CxCx 24 Cx 16 C

1

 

TLR21

t

27

Cx 10 C

CxCx 24 Cx 15 C

1

 

TLR22

t

27

Cx 8 C

CxCx 24 Cx 18 C

1

 

TLR23

t

27

Cx 14 C

CxCx 24 Cx 18 C

1

TLR7

TLR7

H, m, d

27(27–28)

Cx 14 C

CxCx 24 Cx 18 C

2

 

"

t

27

Cx 12 C

CxCx 24 Cx 18 C

2

 

TLR8

h, m, p

27(24–26)

Cx 12 C

CxCx 24 Cx 18 C

2

 

"

t

27

Cx 13 C

CxCx 24 Cx 18 C

2

 

TLR9

h, m, p, b, d, ca, ho, s, mnm

27(26)

Cx 9 C

CxCx 23 Cx 18 C

2

 

"

t, jf, gsb

27

Cx 10 C

CxCx 23 Cx 18 C

2

 

TLR

gp

28, 26

?

CxCx 24 Cx 18 C

2

Others

TLRa

Jl

21

Cx 8 C

CxCx 22 C 12 C

1

 

TLRb

jl

21

Cx 8 C

CxCx 22 Cx 20 C

1

 

TLR15

c

21

No

CxCx 24 Cx 20 C

2

  1. aThe six families and others. bAbbreviations: ab, American bison; as, Atlantic salmon; b, bovine; c, chicken; ca, cat; ch, Chinese hamster; cm, Cynomolgus monkey; d, dog; dwd, Domestic water buffalo; g, goat; go, Goldfish; gp, green puffer; gsb, Gilthead sea bream; h, human; ha, hamster; ho, horse; jf, Japanese flounder; jhm, Japanese house mouse; jl, Japanese lamprey; lg, lowland gorilla; m, mouse; mnm, Ma's night monkey; n, Nilgai; ob, Olive baboon; or, Orangutan; p, pig; pc, Pygmy chimpanzee; r, rat; ra, rabbit; rm, Rhesus macaque; rt, Rainbow trout; s, sheep; t, Takifugu rubripes; z, Zebrafish. cNL; the repeat number of LRRs. The number of parenthesis is NL reported in the Interpro datbase.d LRRNT, the cysteine clusters on the N-terminal side of LRRs; LRRCT, the cysteine clusters on the C-terminal side of LRRs. eNB; the number of horseshoe domains of the LRRs.
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BMC Genomics

ISSN: 1471-2164

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