Figure 2

The distribution of histone modifications against DNA methylation identified by ChIP-chip and DMH with CpG island array. A and B. Positive targets (>2-fold change) from ChIP-chip (both acetyl-H3K9 and dimethyl-H3K9) and/or DMH are selected. The histone acetylation and methylation levels are plotted against DNA methylation status. Histone modification levels in L1210 cells were examined by comparison between ChIP DNA enriched with acetyl- and dimethyl-H3K9 antibody, and the input DNA. DNA methylation status was screened by DMH at Bst UI and Hpa II sites. Mean plots with error bounds were used to indicate the level of histone modifications.