Figure 4

Histone modifications and DNA methylation status in mouse promoter regions. A. Histogram of histone acetylation and dimethylation identified by ChIP-chip with mouse custom promoter array. Brown and green bars indicate the frequency of acetyl-H3K9 and dimethyl-H3K9. Frequency curves are shown as follows: continuous line, acetyl-H3K9; dash line, dimethyl-H3K9. B. Interval plots of histone modifications versus DNA methylation. Histone modifications were plotted with two groups: unmethylated and methylated genes identified by RLGS. The interval bars indicate the distribution of histone modifications with horizontal lines at the endpoints of the 95% confidence interval for the mean and a symbol at the mean.