Figure 1

Amino acid sequence comparison of Fas, FADD and caspase-8 between Medaka and humans. (A) Alignment of Medaka and human Fas. The three lines underneath the sequence indicate the cysteine repeat domains in the extracellular region. The double line and the dotted line indicate the transmembrane region and the death domain (DD) within the cytoplasmic region, respectively. (B) Alignment of Medaka and human FADD. The bold and dotted lines under the sequence indicate the death effector domain (DED) and the DD, respectively. (C) Alignment of Medaka and human caspase-8 (CASP8). The two bold lines and a box indicate the DEDs and the protease domain, respectively. Asterisks represent the amino acids essential for catalytic activity. Identical and similar amino acids between Medaka and human in all alignments are indicated in black and shaded boxes, respectively.