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Table 1 Estrogen-sensitive genes.

From: Sensitive and robust gene expression changes in fish exposed to estrogen – a microarray approach

cGRASP ID

M-value 0.87 ng/L

M-value 10 ng/L

Annotation

CK991165

1.40

5.60

[GO] [P10761] Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Sperm receptor) (Zona pellucida protein C),

CB492227

-0.23

-0.34

[GO] [P23506] Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC 2,1,1,77) (Protein-beta-aspartate methyltransferase) (PIMT) (Protein L- isoaspartyl/D-aspartyl methyltransferase)

CA054422

0.22

0.43

UNKNOWN

CB496664

0.30

0.50

[GO] [Q9D0E1] Heterogeneous nuclear ribonucleoprotein M (hnRNP M),

CB497378

0.27

0.69

[GO] [P15532] Nucleoside diphosphate kinase A (EC 2,7,4,6) (NDK A) (NDP kinase A) (Tumor metastatic process-associated protein) (Metastasis inhibition factor NM23) (NDPK-A) (nm23-M1),

CB511030

0.27

0.47

[GO] [P15532] Nucleoside diphosphate kinase A (EC 2,7,4,6) (NDK A) (NDP kinase A) (Tumor metastatic process-associated protein) (Metastasis inhibition factor NM23) (NDPK-A) (nm23-M1)

CK991305

0.27

0.59

[GO] [Q01768] Nucleoside diphosphate kinase B (EC 2,7,4,6) (NDK B) (NDP kinase B) (nm23-M2) (P18),

CA037915

0.30

0.38

[GO] [P35505] Fumarylacetoacetase (EC 3,7,1,2) (Fumarylacetoacetate hydrolase) (Beta-diketonase) (FAA),

CA060608

0.21

0.46

[GO] [P56384] ATP synthase lipid-binding protein, mitochondrial precursor (EC 3,6,3,14) (ATP synthase proteolipid P3) (ATPase protein 9) (ATPase subunit C),

CB496562

0.16

0.32

[GO] [Q9CY58] Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1),

CB516182

0.46

0.56

[GO] [O08709] Peroxiredoxin 6 (EC 1,11,1,15) (Antioxidant protein 2) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (EC 3,1,1,-) (aiPLA2) (Non-selenium glutathione peroxidase) (EC 1,11,1,7) (NSGPx),

CB511422

0.25

0.50

[GO] [P15532] Nucleoside diphosphate kinase A (EC 2,7,4,6) (NDK A) (NDP kinase A) (Tumor metastatic process-associated protein) (Metastasis inhibition factor NM23) (NDPK-A) (nm23-M1),

CB496931

0.80

2.58

[GO] [P11404] Fatty acid-binding protein, heart (H-FABP) (Heart-type fatty acid- binding protein) (Mammary-derived growth inhibitor) (MDGI),

CB497374

0.60

2.08

[GO] [P11404] Fatty acid-binding protein, heart (H-FABP) (Heart-type fatty acid- binding protein) (Mammary-derived growth inhibitor) (MDGI),

CB505692

-0.33

-0.42

UNKNOWN

CB497174

0.53

1.71

[NR] [XP_423045] PREDICTED: similar to nudix (nucleoside diphosphate linked moiety X)-type motif 7; coenzyme A diphosphatase [Gallus gallus]

CB497649

0.21

0.52

[GO] [Q01768] Nucleoside diphosphate kinase B (EC 2,7,4,6) (NDK B) (NDP kinase B) (nm23-M2) (P18),

CA037988

0.23

0.41

[NT] [AJ488155] Pachymedusa dacnicolor partial mRNA for ribosomal protein S16 (rps16 gene)

CB499596

0.14

0.49

[NR] [NP_077217] hydroxysteroid dehydrogenase like 2 [Mus musculus]

CB489314

-1.01

-1.11

UNKNOWN

CA769854

0.64

2.17

[GO] [P11404] Fatty acid-binding protein, heart (H-FABP) (Heart-type fatty acid- binding protein) (Mammary-derived growth inhibitor) (MDGI),

CB509453

-0.32

-0.48

[GO] [O16797] 60S ribosomal protein L3,

CB500821

-0.26

-0.36

[GO] [P62918] 60S ribosomal protein L8,

CB492885

-0.15

-0.31

UNKNOWN

CA061403

0.42

0.72

UNKNOWN

CB498219

0.24

0.51

[NR] [XP_613218] PREDICTED: similar to 24-dehydrocholesterol reductase precursor, partial [Bos taurus]

CA054168

-0.39

-0.58

UNKNOWN

CB515449

0.34

-0.60

[GO] [P50247] Adenosylhomocysteinase (EC 3,3,1,1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) (Liver copper binding protein) (CUBP),

CB515945

-0.36

-0.49

[NR] [NP_683732] RNA binding motif protein 5 [Mus musculus]

CA057448

-0.30

-0.33

UNKNOWN

CA036745

-0.62

-0.74

[NT] [XM_532501] PREDICTED: Canis familiaris similar to Chimerin (chimaerin) 2 (LOC475267), mRNA

CB509472

-0.29

-0.42

UNKNOWN

CB494192

0.23

0.33

[GO] [P09411] Phosphoglycerate kinase 1 (EC 2,7,2,3),

CB496589

-0.49

-0.82

UNKNOWN

CB513882

-0.48

-0.60

[NR] [XP_413822] PREDICTED: similar to normal mucosa of esophagus specific 1 [Gallus gallus]

CK990857

-0.64

-1.11

UNKNOWN

  1. cDNAs or sets of cDNA putatively sensitive to estrogen exposure as judged by the presence on the top 250-lists ranked by moderated t-statistics on both 0.87 and 10 ng EE2/L exposure experiments in male juvenile rainbow trout. cDNAs corresponding to genes that were selected for qPCR analysis are marked with bold text. Note that several cDNAs may likely correspond to the same gene.