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Table 1 TAM- and EE-induced uterine morphometric changes

From: Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

A)

Dose Response (3 × 24 hr)

TAM Dose (μg/kg)

Luminal Epithelial Cell Height (μm)

Luminal Circumference (mm)

Avg. Number of Glandular Tubules

0

8.75 ± 0.86

0.77 ± 0.14

1

1

8.99 ± 1.00

0.72 ± 0.12

0

3

10.91 ± 2.97

1.17 ± 0.41

1

10

10.73 ± 1.15

1.17 ± 0.29

3

30

15.12 ± 1.55*

1.87 ± 0.26*

5*

100

24.58 ± 2.79*

3.60 ± 0.27*

10*

300

27.08 ± 3.79*

2.68 ± 1.19*

5*

1000

31.30 ± 2.25*

3.05 ± 0.73*

5*

100 EE

28.94 ± 3.35*

+++a

4

B)

Time Course (100 μg/kg)

Time (hrs)

Luminal Epithelial Cell Height (μm)

Luminal Circumference (mm)

 

2

9.98 ± 1.68

0.79 ± 0.19

 

4

8.61 ± 1.58

0.80 ± 0.06

 

8

10.06 ± 2.50

0.96 ± 0.29

 

12

9.46 ± 1.28

0.99 ± 0.21

 

18

9.18 ± 1.03

1.29 ± 0.42

 

24

11.08 ± 1.94*

1.22 ± 0.42

 

3 × 24

28.61 ± 7.50*

2.85 ± 1.83*

 
  1. * Statistically different from time matched vehicle (p < 0.05)
  2. a Lumen larger than 100× field of view, accurate measurements could not be made at 40× magnification Time course vehicle samples are not significantly different from each other.