A) | |||
---|---|---|---|
Dose Response (3 × 24 hr) | |||
TAM Dose (μg/kg) | Luminal Epithelial Cell Height (μm) | Luminal Circumference (mm) | Avg. Number of Glandular Tubules |
0 | 8.75 ± 0.86 | 0.77 ± 0.14 | 1 |
1 | 8.99 ± 1.00 | 0.72 ± 0.12 | 0 |
3 | 10.91 ± 2.97 | 1.17 ± 0.41 | 1 |
10 | 10.73 ± 1.15 | 1.17 ± 0.29 | 3 |
30 | 15.12 ± 1.55* | 1.87 ± 0.26* | 5* |
100 | 24.58 ± 2.79* | 3.60 ± 0.27* | 10* |
300 | 27.08 ± 3.79* | 2.68 ± 1.19* | 5* |
1000 | 31.30 ± 2.25* | 3.05 ± 0.73* | 5* |
100 EE | 28.94 ± 3.35* | +++a | 4 |
B) | |||
Time Course (100 μg/kg) | |||
Time (hrs) | Luminal Epithelial Cell Height (μm) | Luminal Circumference (mm) |  |
2 | 9.98 ± 1.68 | 0.79 ± 0.19 |  |
4 | 8.61 ± 1.58 | 0.80 ± 0.06 |  |
8 | 10.06 ± 2.50 | 0.96 ± 0.29 |  |
12 | 9.46 ± 1.28 | 0.99 ± 0.21 |  |
18 | 9.18 ± 1.03 | 1.29 ± 0.42 |  |
24 | 11.08 ± 1.94* | 1.22 ± 0.42 |  |
3 × 24 | 28.61 ± 7.50* | 2.85 ± 1.83* |  |