Table 1 Genes induced by at least 2 treatments.
DSM code | Predicted protein | ||||
|---|---|---|---|---|---|
Protein Folding | Tun 1 h | Tun 2 h | DTT | tPA | |
An01g13220 | similar to the chaperone LHS1 | 3.4 ± 0.5 | 1.5 ± 0.7 | 2.5 ± 0.3 | 1.7 ± 0.8 |
An02g14800 | Protein disulfide isomerase PDIA | 1.7 ± 0.1 | 2.6 ± 0.1 | 2.2 ± 0.004 | 1.9 ± 0.01 |
An01g04600 | Protein disulfide isomerase PRPA | 3.8 ± 0.2 | 2.6 ± 0.3 | 4.0 ± 0.3 | 2.2 ± 0.2 |
An01g08420 | calnexin CNXA | 3.0 ± 0.3 | 2.3 ± 0.1 | 3.2 ± 0.5 | 2.2 ± 0.1 |
An11g04180 | chaperone BIPA | 3.2 ± 0.7 | 2.6 ± 0.6 | 4.7 ± 0.6 | 2.4 ± 0.008 |
An16g07620 | similar to ER oxidising protein ERO1 | 1.9 ± 0.7 | 2.6 ± 0.4 | 3.1 ± 0.9 | 3.1 ± 0.5 |
An18g02020 | Protein disulfide isomerase TIGA | *1.3 ± 0.5 | 1.7 ± 0.4 | *1.7 ± 0.03 | 1.8 ± 0.02 |
An11g11250 | similar to the chaperone P58IPK Homo sapiens | 2.5 ± 0.6 | 1.9 ± 0.07 | *1.3 ± 0.3 | 1.5 ± 0.05 |
An05g00880 | similar to dnaJ protein homolog SCJ1 | 2.5 ± 0.3 | 1.5 ± 0.06 | 2.1 ± 0.3 | *1.6 ± 0.2 |
Translocation/signal peptidase complex | |||||
An01g13070 | similar to ER protein-translocation complex subunit SEC63 | *1.3 ± 0.5 | 1.6 ± 0.09 | *1.7 ± 0.2 | 2.5 ± 0.1 |
An16g08830 | similar to component of subcomplex SEC71 | 1.8 ± 0.2 | *1.4 ± 0.08 | 1.9 ± 0.4 | *1.7 ± 0.04 |
An17g00090 | similar to translocation complex subunit SEC72 | 1.7 ± 0.2 | 1.6 ± 0.2 | 2.1 ± 0.5 | *1.3 ± 0.1 |
An01g11630 | similar to translocation complex component SSS1 | 2.5 ± 0.2 | 1.6 ± 0.3 | 1.6 ± 0.04 | *1.6 ± 0.1 |
An09g05420 | similar to signal peptidase subunit SPC3 | 2.7 ± 0.3 | 1.8 ± 0.2 | 1.5 ± 0.2 | 1.8 ± 0.8 |
An01g00560 | similar to signal peptidase subunit SEC11 | 2.2 ± 0.4 | 1.9 ± 0.06 | *1.1 ± 0.2 | 1.7 ± 0.009 |
An15g06470 | similar to signal sequence receptor α-subunit | 1.8 ± 0.6 | 1.5 ± 0.07 | *1.5 ± 0.4 | 1.5 ± 0.08 |
Glycosylation | |||||
An14g05910 | similar to mannosyltransferase ALG2 | 2.3 ± 0.5 | *2.9 ± 1.1 | *1.7 ± 0.2 | 1.5 ± 0.1 |
An18g02360 | similar to mannosyltransferase ALG3 | 2.4 ± 0.4 | 4.8 ± 2.1 | *-1.4 ± 0.3 | 2.0 ± 0.3 |
An03g04410 | similar to glucosyltransferase ALG5 | 1.8 ± 0.3 | *1.7 ± 0.001 | 2.2 ± 0.4 | 1.7 ± 0.1 |
An02g03240 | similar to N-acetylglucosaminephosphotransferase ALG7 | 1.8 ± 0.3 | 2.8 ± 0.5 | 2.1 ± 0.1 | *1.7 ± 0.2 |
An07g04190 | similar to glycosyltransferase WBP1 | 1.9 ± 0.2 | 1.8 ± 0.09 | *1.4 ± 0.2 | 1.7 ± 0.09 |
An02g14560 | oligosaccharyltransferase alpha subunit OSTA | 1.7 ± 0.09 | 1.6 ± 0.06 | *-1.4 ± 0.007 | 1.6 ± 0.4 |
An18g03920 | similar to oligosaccharyltransferase subunit OST2 | 1.9 ± 0.4 | 1.5 ± 0.2 | 1.5 ± 0.1 | *1.2 ± 0.2 |
An18g04260 | similar to UDP-galactose transporter HUT1 | 2.3 ± 0.2 | *-1.0 ± 0.5 | 2.1 ± 0.3 | 1.9 ± 0.2 |
An18g06220 | similar to alpha-mannosidase MNS1 | *1.1 ± 0.5 | 2.4 ± 0.6 | *1.2 ± 0.004 | 1.8 ± 0.1 |
An13g00620 | similar to beta subunit of an ER alpha-glucosidase | *1.4 ± 0.5 | 1.9 ± 0.2 | *-1.8 ± 0.1 | 1.7 ± 0.2 |
An15g01420 | similar to glucosidase I CWH41 | *1.3 ± 0.5 | 1.7 ± 0.5 | *-1.8 ± 0.2 | 1.6 ± 0.01 |
An04g05250 | similar to dolichol synthesis protein RER2 | 1.7 ± 0.1 | *1.3 ± 0.08 | 2.2 ± 0.1 | *1.2 ± 0.1 |
An02g14940 | similar to flippase RFT1 | *1.5 ± 0.5 | *-1.0 ± 0.9 | 1.7 ± 0.1 | 1.7 ± 0.1 |
Vesicle trafficking/transport | |||||
An03g04940 | similar to COPII vesicle coat component protein ERV41 | 2.2 ± 0.07 | 1.9 ± 0.08 | 2.4 ± 0.8 | 2.3 ± 0.6 |
An01g04320 | similar to COPII vesicle coat component protein ERV46 | 2.1 ± 0.2 | 2.4 ± 0.3 | *1.5 ± 0.1 | 2.1 ± 0.05 |
An02g04250 | similar to ER protein P58 (lectin family) Rattus norvegicus | 1.7 ± 0.5 | 1.8 ± 0.2 | *1.2 ± 0.01 | 1.5 ± 0.3 |
An02g08450 | secretory gene product NSFA | 1.5 ± 0.2 | *1.2 ± 0.006 | 2.5 ± 0.06 | *1.1 ± 0.06 |
An08g06780 | similar to ER to Golgi transport protein USO1 | 2.0 ± 0.1 | *6.5 ± 3.2 | 5.3 ± 3.6 | *1.7 ± 0.6 |
Proteolytic degradation | |||||
An16g06750 | similar to D-stereospecific aminopeptidase | *2.0 ± 0.5 | 2.1 ± 0.1 | 14.0 ± 8.0 | *2.1 ± 0.2 |
An08g09000 | similar to ubiquitin like protein DSK2 | 1.7 ± 0.4 | *1.0 ± 0.1 | 3.0 ± 0.2 | *-1.1 ± 0.2 |
An09g00950 | similar to aminopeptidase DAP Ochrobactrum anthropi | 1.6 ± 0.2 | *-1.7 ± 0.3 | 6.2 ± 1.4 | *1.1 ± 0.2 |
Lipid/Inositol metabolism | |||||
An02g13410 | similar to acetyl-coenzyme A transporter AT-1 | 2.4 ± 0.04 | 1.8 ± 0.1 | 5.4 ± 0.3 | 2.3 ± 0.2 |
An11g02990 | similar to cytochrome P450 DIT2 | *-1.2 ± 0.5 | *1.2 ± 0.002 | 2.0 ± 0.3 | 1.6 ± 0.03 |
An14g07030 | similar to carboxylesterase Aspergillus fumigatus | *1.6 ± 0.5 | *-1.9 ± 1.2 | 43.0 ± 5.3 | 1.7 ± 0.2 |
Cellular transport | |||||
An12g03150 | similar to multidrug resistance protein ATRD | 2.0 ± 0.4 | *-1.1 ± 0.3 | 10.1 ± 2.5 | *-1.1 ± 0.1 |
Translation | |||||
An14g06610 | similar to elongation factor Eef1 alpha-A chain TEF2 | 1.6 ± 0.1 | *1.6 ± 0.3 | 8.6 ± 1.3 | *1.4 ± 0.3 |
Stress related | |||||
An12g03580 | similar to glutathione S-transferase 3 MGST3 H. sapiens | *1.2 ± 0.5 | *1.3 ± 0.1 | 3.2 ± 0.5 | 5.1 ± 1.4 |
An01g14100 | weakly similar to stress protein HERP Mus musculus | 2.0 ± 0.1 | *1.5 ± 0.2 | 1.5 ± 0.3 | *1.8 ± 0.3 |
Cell Cycle and DNA processing | |||||
An01g08170 | similar to DNA repair endonuclease RAD1 S. pombe | 1.8 ± 0.5 | *1.8 ± 0.2 | 2.2 ± 1.1 | *1.6 ± 0.2 |
C-compound and carbohydrate metabolism | |||||
An09g06400 | similar to chitinase CHIA Aspergillus nidulans | -2.1 ± 0.5 | *1.0 ± 0.008 | 2.4 ± 0.3 | 2.3 ± 0.8 |
An16g09070 | similar to glucosamine-6-phosphate deaminase A. fumigatus | *-1.2 ± 0.5 | *1.4 ± 0.2 | 2.1 ± 0.08 | 2.4 ± 0.7 |
Unclassified | |||||
An08g03960 | hypothetical endoplasmic reticulum associated protein | 2.1 ± 0.09 | 1.7 ± 0.07 | 3.3 ± 1.0 | 1.6 ± 0.06 |
An02g00120 | hypothetical protein | *2.4 ± 0.5 | *1.2 ± 0.3 | 2.0 ± 0.5 | 1.8 ± 0.07 |
An08g03970 | hypothetical protein | *1.7 ± 0.5 | 2.0 ± 0.4 | *1.2 ± 0.02 | 1.8 ± 0.1 |
An09g00650 | hypothetical protein | 2.0 ± 0.3 | *-1.30.4 | 2.7 ± 0.2 | 4.0 ± 1.4 |
An17g00660 | hypothetical protein | *-1.1 ± 0.2 | *-1.5 ± 0.6 | 5.0 ± 2.7 | 1.6 ± 0.1 |
An11g06970 | hypothetical protein | *3.1 ± 0.3 | *1.7 ± 0.7 | 17.3 ± 6.0 | 2.3 ± 0.6 |
An16g00070 | hypothetical protein | *-1.4 ± 0.5 | *1.1 ± 0.1 | 5.1 ± 0.1 | 1.5 ± 0.2 |
An16g08470 | hypothetical protein | *1.8 ± 0.3 | *1.1 ± 0.2 | 1.5 ± 0.1 | 1.5 ± 0.05 |
An02g14500 | hypothetical protein | *-1.2 ± 0.4 | *1.0 ± 0.1 | 9.3 ± 2.7 | 1.7 ± 0.1 |
An03g00720 | hypothetical protein | *1.1 ± 0.5 | *-1.2 ± 0.06 | 2.6 ± 1.1 | 1.9 ± 0.7 |
An04g02250 | questionable ORF | *2.2 ± 0.3 | 2.0 ± 0.2 | 20.2 ± 10.3 | *1.3 ± 0.006 |
An14g01990 | hypothetical protein | 3.0 ± 0.4 | *-1.4 ± 0.2 | 4.3 ± 0.9 | *-1.1 ± 0.03 |
An08g04260 | hypothetical protein | 2.0 ± 0.6 | *1.7 ± 0.3 | 2.4 ± 0.01 | *1.3 ± 0.07 |
An07g10280 | hypothetical protein | 2.0 ± 0.7 | *1.6 ± 0.08 | 1.8 ± 0.9 | *1.6 ± 0.2 |
An09g06130 | hypothetical protein | 2.0 ± 0.3 | *2 ± 0.2 | 1.6 ± 0.4 | *1.4 ± 0.09 |
An08g09860 | hypothetical protein | 2.3 ± 0.6 | *1.2 ± 0.4 | 7.4 ± 1.0 | *-1.4 ± 0.1 |
An18g06120 | similar to secreted protein vc33_1 | 1.9 ± 0.2 | *-1.1 ± 0.1 | 2.2 ± 0.1 | *1.0 ± 0.05 |
An14g06550 | hypothetical protein | 2.1 ± 0.3 | *1.2 ± 0.1 | 2.8 ± 0.6 | *1.2 ± 0.1 |
An15g02650 | hypothetical protein | 2.8 ± 1.5 | *1.1 ± 0.2 | 2.8 ± 0.6 | *1.1 ± 0.1 |
An11g10800 | similar to probable isochorismatase | 2.3 ± 0.3 | *1.0 ± 0.002 | 11.5 ± 2.2 | *1.2 ± 0.2 |
An18g01690 | hypothetical protein | 2.3 ± 1.5 | *2.1 ± 0.5 | 2.4 ± 0.9 | *1.1 ± 0.1 |
An16g08680 | hypothetical protein | 1.7 ± 0.4 | *-1.1 ± 0.2 | 6.7 ± 0.5 | *1.1 ± 0.07 |