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Figure 1 | BMC Genomics

Figure 1

From: Comprehensive genetic and epigenetic analysis of sporadic meningioma for macro-mutations on 22q and micro-mutations within the NF2 locus

Figure 1

Summary of array-CGH profiles for chromosome 22 insporadic meningioma. A) Detailed summary of all complex aberrations. Deletions and gains are mapped according to the clones present on the chromosome 22 minimal tiling path array. Chromosome 22 clones are grouped in bins of 10 along the y-axis. The panel of tumors which displayed complex aberrations of chromosome 22 is shown from left to right. The red, yellow and blue boxes denote hemizygous deletion, biallelic deletion and gain, respectively. The horizontal dashed line displays the approximate position of the NF2 gene in relation to the measurement points on the chromosome 22 minimal tiling path array. The table below details the clone ID's at which the deletion/gain starts and finishes. Smallest regions of overlapping deletions are highlighted with grey lines (R1 and R2) and genes present within these regions are shown to the left. Tumor names highlighted in bold are displayed in more detail in other figures. B) Detailed view of candidate region 1 (R1) with gene and clone information presented according to the positions on chromosome 22 sequence (UCSC Homo sapiens Genome Browser, assembly July 2003). C) Detailed view of candidate region 2 (R2) with gene and clone information presented according to the positions on chromosome 22 sequence (UCSC Homo sapiens Genome Browser, assembly July 2003).

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