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Table 4 Phenotypic changes in mice carrying loss-of-function mutations of the predicted brain and PBMC target genes.

From: Characterization of microRNA expression profiles in normal human tissues

Phenotype Brain PBMC Random
Nervous system1 21 5 5
Immune system2 2 8 7
Nervous/immune3 2 6 2
Embryonic lethal4 2 0 4
Other systems5 3 4 11
Normal6 1 7 4
Total gene number 31 30 33
  1. 1 Phenotype in nervous system, including behavioral and neurological defects, but no defects in immune and hematopoietic system.
  2. 2 Phenotype in immune system, including the hematopoietic system, but no nervous system or behavioral/neurological defects.
  3. 3 Phenotype from both 1 and 2 can be seen.
  4. 4 Embryonic lethal with no other phenotypic records, indicating that the embryo dies too early to observe meaningful phenotype.
  5. 5 Defects in other tissues/organs/systems than nervous and immune systems.
  6. 6 The phenotypic record showed no defect was seen.
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BMC Genomics

ISSN: 1471-2164

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