Table 1 Selected FAS target genes involved in proliferation/apoptosis, metabolism, transcription and protein ubiquitination.

Proliferation

   Up-regulated

Cell division cycle associated 4

CDCA4

1.43

1.63

1.82

1.59

GI_22027510-A

Cyclin G1

CCNG1

0.94

1.55

1.41

1.37

GI_40805830-S

Cyclin-dependent kinase 2

CDK2

1.14

1.60

1.43

1.39

GI_16936529-A

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A

1.60

1.60

1.84

1.82

GI_17978496-A

Polo-like kinase 1

PLK1

1.24

1.35

1.48

1.59

GI_34147632-S

Sprouty homolog 2

SPRY2

1.39

1.68

1.60

1.58

GI_22209007-S

Sprouty homolog 4

SPRY4

1.08

1.43

1.45

1.56

GI_23308573-S

Sprouty-related, EVH1 domain containing 1

SPRED1

1.18

1.36

1.59

1.47

GI_22749220-S

WEE1 homolog

WEE1

1.37

1.55

1.65

1.67

GI_19718775-S

Apoptosis

   Up-regulated

Annexin A1

ANXA1

1.29

1.93

1.90

1.63

GI_4502100-S

Apoptotic protease activating factor

APAF1

1.28

1.72

1.48

1.39

GI_32483362-A

CSE1 chromosome segregation 1-like

CSE1L

1.05

1.46

2.40

2.07

GI_29029560-I

P21 (CDKN1A)-activated kinase 2

PAK2

1.13

1.44

1.46

1.71

GI_32483398-S

Sphingosine-1-phosphate lyase 1

SGPL1

1.42

1.55

1.67

1.72

GI_31982935-S

Tumor necrosis factor receptor superfamily, member 10b

TNFRSF10B

1.32

1.81

1.76

1.49

GI_22547118-A

Tumor necrosis factor receptor superfamily, member 21

TNFRSF21

1.20

1.71

1.88

1.73

GI_23238206-S

Metabolism

   Up-regulated

Insulin induced gene 1

INSIG1

1.51

1.51

1.56

1.51

GI_38327530-A

Leptin receptor

LEPR

1.30

1.60

1.63

1.59

GI_41327153-S

Leptin receptor overlapping transcript-like 1

LEPROTL1

1.11

1.62

1.59

1.45

GI_7662509-S

Transcription

   Up-regulated

E2F transcription factor 7

E2F7

1.26

1.32

1.50

1.47

GI_44955909-S

Early growth response 1

EGR1

1.56

1.56

1.84

1.82

GI_31317226-S

Far upstream element (FUSE) binding protein 1

FUBP1

1.15

1.12

1.51

1.52

GI_17402899-S

FBJ murine osteosarcoma viral oncogene homolog B

FOSB

1.44

1.40

1.66

1.78

GI_5803016-S

FOS-like antigen 1

FOSL1

1.11

1.44

1.65

1.59

GI_34734076-S

Kruppel-like factor 4 (gut)

KLF4

1.04

1.47

1.61

1.36

GI_34916057-S

Meis1, myeloid ecotropic viral integration site 1 homolog

MEIS1

1.12

1.50

1.33

1.30

GI_45006902-S

Nuclear factor I/A

NFIA

1.13

1.40

1.41

1.52

GI_30840979-S

Nuclear factor I/B

NFIB

2.10

2.24

2.29

2.16

GI_5031940-S

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

NFATC3

1.31

1.52

1.48

1.50

GI_27886558-A

Paired related homeobox 1

PRRX1

0.96

1.35

1.59

1.59

GI_12707576-A

Protein phosphatase 1, regulatory (inhibitor)

ELF2

1.30

1.34

1.54

1.41

GI_42544175-A

Serum response factor

SRF

1.55

1.44

1.35

1.26

GI_4507204-S

SP110 nuclear body protein

SP110

1.02

1.25

1.33

1.63

GI_17986251-I

Zinc finger protein 106 homolog

ZFP106

1.33

1.58

1.66

1.68

GI_11968022-S

Zinc finger protein 267

ZNF267

1.25

1.53

1.75

1.52

GI_24431954-S

Zinc finger protein 35 (clone HF.10)

ZNF35

1.55

1.70

1.60

1.58

GI_21361560-S

Zinc finger protein 426

ZNF426

1.36

1.52

1.37

1.35

GI_13129115-S

Zinc finger protein 503

ZNF503

1.28

1.53

1.37

1.28

GI_34222201-S

Zinc finger protein 539

ZNF539

1.04

1.50

1.29

1.13

GI_4758513-S

Zinc finger protein 559

ZNF559

1.48

1.76

1.59

1.53

GI_23618925-S

Zinc finger protein 586

ZNF586

1.73

1.63

1.63

1.51

GI_8923076-S

Zinc finger protein 91 homolog

ZFP91

1.13

1.42

1.60

1.26

GI_25777699-I

   Down-regulated

Aryl-hydrocarbon receptor nuclear translocator 2

ARNT2

0.85

0.79

0.62

0.76

GI_41281514-S

CAMP responsive element binding protein 3-like 4

CREB3L4

0.92

0.66

0.66

0.76

GI_31542090-S

Hypothetical protein FLJ37970

FLJ37970

1.08

0.79

0.81

0.67

GI_40795670-S

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

ID2

1.00

0.79

0.61

0.71

GI_33946335-S

Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

ID3

0.93

0.69

0.57

0.56

GI_32171181-S

Neuronal PAS domain protein 1

NPAS1

0.90

0.82

0.71

0.64

GI_22027481-S

Oligodendrocyte transcription factor 1

OLIG1

0.78

0.83

0.69

0.68

GI_41281694-S

Signal transducer and activator of transcription 2, 113 kDa

STAT2

0.90

0.86

0.64

0.71

GI_38202247-S

Ubiquitination

   Up-regulated

Ubiquitin-conjugating enzyme E2 variant 1

UBE2V1

1.79

2.54

2.45

2.11

GI_40806192-S

Ubiquitin-conjugating enzyme E2 variant 1

UBE2V1

1.65

1.73

1.83

1.67

GI_40806191-I

Ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog)

UBE2E3

1.62

2.21

2.27

2.14

GI_33359693-A

Ubiquitin-conjugating enzyme E2C

UBE2C

1.09

1.11

1.52

1.25

GI_32967282-I

CDC23 (cell division cycle 23, yeast, homolog)

CDC23

1.24

1.75

1.67

1.60

GI_16554575-S

Ring finger protein 144

RNF144

1.52

1.52

1.47

1.51

GI_38045937-S

Makorin, ring finger protein, 1

MKRN1

1.41

1.75

1.64

1.49

GI_21359891-S

F-box and leucine-rich repeat protein 12

FBXL12

1.56

1.81

1.55

1.61

GI_8923178-S

F-box and leucine-rich repeat protein 7

FBXL7

1.52

1.62

1.64

1.68

GI_21071079-S

Ubiquitin-like, containing PHD and RING finger domains, 1

UHRF1

1.15

1.55

1.36

1.35

GI_16507203-S

APG12 autophagy 12-like

APG12L

1.32

1.27

1.54

1.24

GI_38261968-S

   Down-regulated

Membrane-associated ring finger (C3HC4) 2

MARCH-II

0.99

0.72

0.60

0.59

GI_31543081-S

SH3 domain containing ring finger 2

SH3RF2

1.00

0.89

0.84

0.66

GI_22749146-S

Tripartite motif-containing 2

TRIM2

0.78

0.83

0.60

0.76

GI_15011942-S

Tripartite motif-containing 37

TRIM37

0.75

0.64

0.64

0.70

GI_15147332-S