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Table 1 Selected FAS target genes involved in proliferation/apoptosis, metabolism, transcription and protein ubiquitination.

From: Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer

Gene Classication/Description Symbol 12 h Fold Δ 24 h Fold Δ 36 h Fold Δ 48 h Fold Δ Gene Identifier
Proliferation       
   Up-regulated       
Cell division cycle associated 4 CDCA4 1.43 1.63 1.82 1.59 GI_22027510-A
Cyclin G1 CCNG1 0.94 1.55 1.41 1.37 GI_40805830-S
Cyclin-dependent kinase 2 CDK2 1.14 1.60 1.43 1.39 GI_16936529-A
Cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A 1.60 1.60 1.84 1.82 GI_17978496-A
Polo-like kinase 1 PLK1 1.24 1.35 1.48 1.59 GI_34147632-S
Sprouty homolog 2 SPRY2 1.39 1.68 1.60 1.58 GI_22209007-S
Sprouty homolog 4 SPRY4 1.08 1.43 1.45 1.56 GI_23308573-S
Sprouty-related, EVH1 domain containing 1 SPRED1 1.18 1.36 1.59 1.47 GI_22749220-S
WEE1 homolog WEE1 1.37 1.55 1.65 1.67 GI_19718775-S
Apoptosis       
   Up-regulated       
Annexin A1 ANXA1 1.29 1.93 1.90 1.63 GI_4502100-S
Apoptotic protease activating factor APAF1 1.28 1.72 1.48 1.39 GI_32483362-A
CSE1 chromosome segregation 1-like CSE1L 1.05 1.46 2.40 2.07 GI_29029560-I
P21 (CDKN1A)-activated kinase 2 PAK2 1.13 1.44 1.46 1.71 GI_32483398-S
Sphingosine-1-phosphate lyase 1 SGPL1 1.42 1.55 1.67 1.72 GI_31982935-S
Tumor necrosis factor receptor superfamily, member 10b TNFRSF10B 1.32 1.81 1.76 1.49 GI_22547118-A
Tumor necrosis factor receptor superfamily, member 21 TNFRSF21 1.20 1.71 1.88 1.73 GI_23238206-S
Metabolism       
   Up-regulated       
Insulin induced gene 1 INSIG1 1.51 1.51 1.56 1.51 GI_38327530-A
Leptin receptor LEPR 1.30 1.60 1.63 1.59 GI_41327153-S
Leptin receptor overlapping transcript-like 1 LEPROTL1 1.11 1.62 1.59 1.45 GI_7662509-S
Transcription       
   Up-regulated       
E2F transcription factor 7 E2F7 1.26 1.32 1.50 1.47 GI_44955909-S
Early growth response 1 EGR1 1.56 1.56 1.84 1.82 GI_31317226-S
Far upstream element (FUSE) binding protein 1 FUBP1 1.15 1.12 1.51 1.52 GI_17402899-S
FBJ murine osteosarcoma viral oncogene homolog B FOSB 1.44 1.40 1.66 1.78 GI_5803016-S
FOS-like antigen 1 FOSL1 1.11 1.44 1.65 1.59 GI_34734076-S
Kruppel-like factor 4 (gut) KLF4 1.04 1.47 1.61 1.36 GI_34916057-S
Meis1, myeloid ecotropic viral integration site 1 homolog MEIS1 1.12 1.50 1.33 1.30 GI_45006902-S
Nuclear factor I/A NFIA 1.13 1.40 1.41 1.52 GI_30840979-S
Nuclear factor I/B NFIB 2.10 2.24 2.29 2.16 GI_5031940-S
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 NFATC3 1.31 1.52 1.48 1.50 GI_27886558-A
Paired related homeobox 1 PRRX1 0.96 1.35 1.59 1.59 GI_12707576-A
Protein phosphatase 1, regulatory (inhibitor) ELF2 1.30 1.34 1.54 1.41 GI_42544175-A
Serum response factor SRF 1.55 1.44 1.35 1.26 GI_4507204-S
SP110 nuclear body protein SP110 1.02 1.25 1.33 1.63 GI_17986251-I
Zinc finger protein 106 homolog ZFP106 1.33 1.58 1.66 1.68 GI_11968022-S
Zinc finger protein 267 ZNF267 1.25 1.53 1.75 1.52 GI_24431954-S
Zinc finger protein 35 (clone HF.10) ZNF35 1.55 1.70 1.60 1.58 GI_21361560-S
Zinc finger protein 426 ZNF426 1.36 1.52 1.37 1.35 GI_13129115-S
Zinc finger protein 503 ZNF503 1.28 1.53 1.37 1.28 GI_34222201-S
Zinc finger protein 539 ZNF539 1.04 1.50 1.29 1.13 GI_4758513-S
Zinc finger protein 559 ZNF559 1.48 1.76 1.59 1.53 GI_23618925-S
Zinc finger protein 586 ZNF586 1.73 1.63 1.63 1.51 GI_8923076-S
Zinc finger protein 91 homolog ZFP91 1.13 1.42 1.60 1.26 GI_25777699-I
   Down-regulated       
Aryl-hydrocarbon receptor nuclear translocator 2 ARNT2 0.85 0.79 0.62 0.76 GI_41281514-S
CAMP responsive element binding protein 3-like 4 CREB3L4 0.92 0.66 0.66 0.76 GI_31542090-S
Hypothetical protein FLJ37970 FLJ37970 1.08 0.79 0.81 0.67 GI_40795670-S
Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein ID2 1.00 0.79 0.61 0.71 GI_33946335-S
Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein ID3 0.93 0.69 0.57 0.56 GI_32171181-S
Neuronal PAS domain protein 1 NPAS1 0.90 0.82 0.71 0.64 GI_22027481-S
Oligodendrocyte transcription factor 1 OLIG1 0.78 0.83 0.69 0.68 GI_41281694-S
Signal transducer and activator of transcription 2, 113 kDa STAT2 0.90 0.86 0.64 0.71 GI_38202247-S
Ubiquitination       
   Up-regulated       
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 1.79 2.54 2.45 2.11 GI_40806192-S
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 1.65 1.73 1.83 1.67 GI_40806191-I
Ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog) UBE2E3 1.62 2.21 2.27 2.14 GI_33359693-A
Ubiquitin-conjugating enzyme E2C UBE2C 1.09 1.11 1.52 1.25 GI_32967282-I
CDC23 (cell division cycle 23, yeast, homolog) CDC23 1.24 1.75 1.67 1.60 GI_16554575-S
Ring finger protein 144 RNF144 1.52 1.52 1.47 1.51 GI_38045937-S
Makorin, ring finger protein, 1 MKRN1 1.41 1.75 1.64 1.49 GI_21359891-S
F-box and leucine-rich repeat protein 12 FBXL12 1.56 1.81 1.55 1.61 GI_8923178-S
F-box and leucine-rich repeat protein 7 FBXL7 1.52 1.62 1.64 1.68 GI_21071079-S
Ubiquitin-like, containing PHD and RING finger domains, 1 UHRF1 1.15 1.55 1.36 1.35 GI_16507203-S
APG12 autophagy 12-like APG12L 1.32 1.27 1.54 1.24 GI_38261968-S
   Down-regulated       
Membrane-associated ring finger (C3HC4) 2 MARCH-II 0.99 0.72 0.60 0.59 GI_31543081-S
SH3 domain containing ring finger 2 SH3RF2 1.00 0.89 0.84 0.66 GI_22749146-S
Tripartite motif-containing 2 TRIM2 0.78 0.83 0.60 0.76 GI_15011942-S
Tripartite motif-containing 37 TRIM37 0.75 0.64 0.64 0.70 GI_15147332-S
  1. The fold change values represent the average from at least 3 of the FAS siRNA duplexes compared to non-silencing control siRNA. Genes were classified using GO terminology from GeneSpring and the NCBI Nucleotide database. For detailed annotations of all 279 differentially expressed genes see Additional File 5.