Figure 4
From: Evidence for systems-level molecular mechanisms of tumorigenesis
Topological and functional association of CGPs. (a). Matrices of network distances between prostate CGPs (three categories: < 4 shortest distance shown in red; 4–6 shown in green; and > 6 shown in blue). CGP matrix clusters with significant enrichment in GO or KEGG annotations involved in tumorigenesis-related processes are indicated. (b). Functional association of prostate CGPs. Cell communication (cluster C) and cell death (cluster G) biological processes are shown. Green, red and black nodes correspond to down-regulated, up-regulated, and non-differentially expressed proteins, respectively. Dashed circles and lines connect proteins common to both processes. Protein kinase C isozymes are denoted by the prefix PRKC.