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Table 3 Selected Opsithorchis viverrini contigs that encode families of secreted/membrane proteins that potentially interact with or are exposed to host tissues. Genera of the closest homologues from BLAST × (nr) searches are shown. Where the closest homologue was from a vertebrate (bold font), a tBLASTx search against dbEST was conducted.

From: Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini

Predicted function Examples/comments and genera of closest orthologues/paralogues Contigs %identities
TGF-β receptor bone morphogenic protein receptor type I (Sus nr/ Macaca est) OvAE22 44
Seven transmembrane receptor DC-STAMP (Strongylocentrotus); laminin receptor (Bos nr/ Clonorchis est) OvAE92, OvAE1722 51
Tetraspanin stabilize cell membranes – expressed in the tegument of schistosomes (Schistosoma) OvAE953 34
C1 family papain-like cysteine protease cathepsin L (Paragonimus), cathepsin B (Fasciola; Clonorchis) OvAE1795, OvAE813, OvAE1171, OvAE532, OvAE1070, OvAE1613, OvAE1711, OvAE615, OvAE398 > 80
C13 family asparaginyl endopeptidase legumain (O. viverrini) OvAE1624, OvAE1824 94
S1 family serine protease HtrA-like (Macaca nr/ Schistosoma est) and kallikrein-like (Schistosoma) peptidases OvAE622, OvAE1918 47–53
A1 family aspartic protease cathepsin D-like; digestive enzyme in helminths (Clonorchis) OvAE1300 80
M41 family metalloprotease mitochondrial membrane proteinase (Schistosoma) OvAE65 91
Granulin mitogen associated with cancer (Bos nr/ Clonorchis est) OvAE1732 45
Aquaporin water channel protein (Schistosoma) OvAE6 48
Tyrosinase critical for S. mansoni egg shell production (Schistosoma) OvAE1900, OvAE1854 63
Phospholipase A2 similar to vertebrate venom proteins; (Heloderma nr/ Clonorchis est) OvAE1644 55
Thioredoxin peroxidase immunomodulatory in fasciolosis (Schistosoma) OvAE54 74
EF-hand secreted Ca2+-binding protein calumenin (Rattus nr/ Xenopus est) OvAE61 47
Saposin-like protein pore forming; similar to fluke cytolysins (Clonorchis) OvAE1692 64
Pathogenesis related protein similar to helminth venom allergen homologues (Schistosoma) OvAE534, OvAE1862 38
Glutathione-S-transferase detoxification of heme and free radicals (Clonorchis) OvAE1057, OvAE1892, OvAE1601, OvAE1729 86
Synaptobrevin neurotransmission/vesicular docking – vesicle associated (Schistosoma) OvAE1001 73
Innexin integral membrane protein forming gap junctions (Schistosoma) OvAE631 78
Fibroblast growth factor (FGF) receptor substrate 2 host FGF is essential for growth of schistosomes (Schistosoma) OvAE1563 32
Ly6c Immune cell differentiation antigen OvAE82 26