Table 4 Opisthorchis viverrini ESTs with sequence identity to mRNAs encoding proteins efficacious as vaccines against other flatworm and nematode parasites.
From: Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini
Predicted protein family | Vaccine antigen and helminth targeted | References |
|---|---|---|
Aspartic protease | APR-1 for hookworm; cathepsin D for Schistosoma japonicum | [59, 60] |
Glutathione-S-transferase | Ac-GST-1 for hookworm; bilvax for schistosomes | [79, 80] |
Cysteine protease | TSBP for Haemonchus contortus; Ac CP1 for hookworm; Cathepsins L1 and L2 for Fasciola hepatica | [61–63] |
Tetraspanin | TSP-1, TSP-2 and Sm23 for Schistosoma mansoni | [33, 81] |
Pathogenesis related protein | ASP-2 for hookworm; ASP-1 for Onchocerca volvulus | [82, 83] |
calpain | Smp80 for schistosomes | [64] |
Fatty acid binding protein | Sm14 for S. mansoni and F. hepatica | [66, 67] |
Saposin-like protein | FhSAP-2 for F. hepatica | [65] |
14-3-3 | Sm14-3-3 for schistosomes | [84] |
22.6 (unknown function) | Sm22.6 for S. mansoni | [58] |