TY - JOUR AU - Jin, Hong AU - Tan, Sipin AU - Hermanowski, Jane AU - Böhm, Sabrina AU - Pacheco, Sabrina AU - McCauley, Joanna M. AU - Greener, Marc J. AU - Hinits, Yaniv AU - Hughes, Simon M. AU - Sharpe, Paul T. AU - Roberts, Roland G. PY - 2007 DA - 2007/01/17 TI - The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms JO - BMC Genomics SP - 19 VL - 8 IS - 1 AB - Dystrophins and dystrobrevins are distantly related proteins with important but poorly understood roles in the function of metazoan muscular and neuronal tissues. Defects in them and their associated proteins cause a range of neuromuscular disorders. Members of this superfamily have been discovered in a relatively serendipitous way; we set out to compile a comprehensive description of dystrophin- and dystrobrevin-related sequences from available metazoan genome sequences, validated in representative organisms by RT-PCR, or acquired de novo from key species. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-8-19 DO - 10.1186/1471-2164-8-19 ID - Jin2007 ER -