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Table 1 Functional annotation of selected overrepresented Gene Ontology categories as determined by EASE

From: Effects of DNA-targeted ionizing radiation produced by 5-[125I]iodo-2'-deoxyuridine on global gene expression in primary human cells

 

Up-regulation

Down-regulation

Cell Line

Biological processes

EASE score

Biological processes

EASE score

AG09319

  

Cytokinesis

1.09E-15

 

Regulation of enzyme activity

0.0001

Cell cycle

9.68E-13

 

Regulation of protein kinase activity

0.0013

M phase

1.95E-12

 

Regulation of cell size

0.0038

DNA metabolism

1.62E-07

 

Negative regulation of signal

 

RNA processing

3.32E-06

 

transduction

0.0116

Chromosome organization

0.0001

 

Regulation of cell proliferation

0.0158

Cytoskeleton organization

0.0002

 

Positive regulation of apoptosis

0.0186

DNA replication

0.0002

 

Activation of MAPK

0.0236

DNA repair

0.0013

 

Cell redox homeostasis

0.0485

Response to DNA damage

0.0021

   

DNA packaging

0.0022

   

Primary metabolism

0.0083

GM05388 (3.7 kBq//ml)

Regulation of protein kinase activity

0.0014

DNA base excision repair

0.0022

 

Regulation of enzyme activity

0.0048

DNA metabolism

0.0134

 

Cell cycle arrest

0.0335

DNA packaging

0.0174

 

Cell cycle

0.0453

Chromosome organization

0.022

   

Cytoskeleton organization

0.0376

GM05388(18.5 kBq/ml)

Cell death

0.0028

M phase

7.63E-06

 

G1/S transition of mitotic cell cycle

0.0067

Chromosome organization

0.0004

   

Cell cycle

0.0008

   

Cytokinesis

0.0058

   

DNA packaging

0.0139

   

Protein metabolism

0.0430