Figure 6

Gene structure of the human ACE3 gene. The restored ancestral ACE3 is compared to three known ACE transcripts (somatic ACE (sACE), testicular ACE (tACE) and ACE isoform 3). ACE3 can be partly reconstructed from the ACE isoform 3 transcript. For clarity, only relevant exons are shown. Exons (black), introns (grey). Exons numbered according to NCBI gene annotation (ACE) and by comparison to other ACE3 sequences (ACE3). Individual ACE3 exons are identical to isoform 3 except for exons 2 and 11 (both have extra base pairs). Exons 28, 31 and 35 are not part of ACE3 (non-ACE like exons). Exons 1, 4 and part of exon 2 are spliced out in the isoform 3 transcript. * indicates stop codons; ** restored ACE3 stop codon (adapted from NCBI GeneID:1636).