Figure 4

Correlation analysis of SAS pair expression in multiple MOE430 data sets. A) Exemplary screenshot of the contig view panel from the ENSEMBL Genome Browser for one of the 179 found probe set pairs with probe sets in sense and antisense orientation, respectively. B) Exemplary scatterplots of the expression values for two SAS probe set pairs. Left: no correlation between probesets 1437874_s_at and 1426591_at; right: positive correlation for the sense (1418840_at) and antisense (1456393_at) probe set pair shown in A). Data represents vsn-normalized and scaled expression values (unit:natural logarithm) from 1637 mouse MOE420 2.0 microarrays downloaded from the Gene Expression Omnibus database. Correlation was calculated using Pearson Correlation. C) Left panel: Distribution of Pearson correlation coefficients using the data matrix described in B) for 179 SAS probe set pairs (gray bars) and 150 randomly picked control probeset pairs (hatched bars). Right panel: same as left, but with Pearson Correlation performed for each individual dataset.