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Table 3 List of the identified eh1-like motifs in ten subclasses of chordate Fox proteins.

From: Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators

Subclass Protein Motifa Homology to eh1 motifb Positionc Protein length Species Accession number
A        
  FoxA1 FSINNLM S 75% 359–366 427 D. rerio AAH65668
  FoxA1a FSINNLM S 75% 356–363 428 X. laevis AAN76331
  FoxA1b FSINNLM S 75% 355–362 427 X. laevis AAA17050
  FoxA1 FSINNLM S 75% 394–401 466 R. norvegicus 6981034
  FoxA1 FSINNLM S 75% 396–403 468 M. musculus P35582
  FoxA1 FSINNLM S 75% 400–407 472 H. sapiens 24497501
  FoxA2 FSINNLM S 75% 342–349 409 D. rerio 18858687
  FoxA2a FSINNLM S 75% 351–358 434 X. laevis 45361699
  FoxA2 FSINNLM S 75% 354–361 438 G. gallus NP990101
  FoxA2 FSINNLM S 75% 377–384 459 M. musculus 6753898
  FoxA2 FSINNLM S 75% 376–383 458 R. norvegicus NP036875
  FoxA2 FSINNLM S 75% 376–383 457 H. sapiens 24497504
  FoxA3 FSITNLM S 87.5% 376–383 441 D. rerio 18858689
  FoxA3 FSITNLM S 87.5% 259–266 324 S. salar AAC16333
  FoxA3 FSINNLM S 75% 307–314 353 M. musculus 22477526
  FoxA3 FSINNLM S 75% 394–401 466 R. norvegicus CAA39418.1
  FoxA3 FSINNLM S 75% 304–311 350 H. sapiens 24497506
  FoxA4 FSITNLM S 87.5% 345–352 417 A. mexicanum AAC60128
  FoxA4a FSITQLM S 75% 328–335 399 X. laevis CAA46290
  FoxA4b FSITQLM S 75% 328–335 400 X. laevis AAB22027
  FoxA5 FSISSLM N 62.5% 452–459 587 C. intestinalis AAB61227
  FoxA5 FSISNLM S 87.5% 342–349 403 B. floridae CAA65368
  FoxA5 FSISSLM N 62.5% 441–448 567 M. oculata AAB69278
B        
  FoxB FSIENII S 87.5% 305–312 475 C. intestinalis CAD58964
  FoxB FNIENII A 62.5% 181–188 289 B. floridae CAD44627
  FoxB1 FAIENII A 62.5% 164–171 297 D. rerio AAH56754
  FoxB1 FAIESII A 62.5% 171–178 289 T. nigroviridis 47209343
  FoxB1 FAIENII A 62.5% 167–174 319 X. laevis AAC62623
  FoxB1a FAIENII A 62.5% 170–177 325 M. musculus Q64732
  FoxB1b FAIENII A 62.5% 169–176 324 M. musculus X92592
  FoxB1 FAIENII A 62.5% 170–178 324 H. sapiens Q99853
  FoxB2 FAIENII G 62.5% 176–183 317 X. laevis CAD31848
  FoxB2 FAIENII G 62.5% 267–274 428 M. musculus NP032049
  FoxB2 FAIENII G 62.5% 266–273 425 R. norvegicus 109459945
  FoxB2 FAIENII G 62.5% 270–277 432 H. sapiens 61966923
C        
  FoxC FSVDNIM T 75% 233–300 497 B. floridae 57337372
  FoxC1.1 FSVDNIM T 62.5% 277–284 476 D. rerio AF219949
  FoxC1.2 FSMDTIM T 75% 254–261 433 D. rerio AF219950
  FoxC1 FSMDTIM T 75% 275–282 470 T. nigroviridis 47220394
  FoxC1 FSVDNIM T 75% 298–305 495 X. laevis 80478512
  FoxC1 FSVDNIM T 75% 275–282 528 G. gallus CAA76851
  FoxC1 FSVDNIM T 75% 308–315 553 M. musculus AAH52011
  FoxC1 FSVDNIM T 75% 307–314 502 B. taurus 76639995
  FoxC1a FSVDNIM T 75% 308–315 553 H. sapiens Q12948
  FoxC1b FSVDNIM T 75% 308–315 553 H. sapiens AAC72915
  FoxC2 FSVENIM T 75% 258–265 463 X. laevis 47497986
  FoxC2 FSVENIM T 75% 244–251 445 G. gallus AAC60065
  FoxC2 FSVETIM T 75% 269–276 494 M. musculus Q61850
  FoxC2 FSVENIM T 75% 270–277 501 H. sapiens Q99958
D        
  FoxD FSIESLI G 62.5% 377–384 506 C. savignyi BAB68347
  FoxD FSIENII G 75% 311–318 402 B. floridae AF512537
  FoxD1 FSIDNII G 75% 295–302 363 D. rerio AAH75922
  FoxD1.1 FSIDSII G 62.5% 277–284 343 D. rerio 45501117
  FoxD1 FSIESII G 62.5% 294–301 345 X. laevis 3892202
  FoxD1 FSIESII G 62.5% 377–384 440 G. gallus AAB08467
  FoxD1 FSIESLI G 62.5% 364–371 455 R. norvegicus XP001057782
  FoxD1 FSIESLI G 62.5% 365–372 456 M. musculus AAC42042
  FoxD1 FSIESII G 62.5% 362–369 465 H. sapiens Q16676
  FoxD2 FSIDNII G 75% 276–283 346 X. laevis CAC69867
  FoxD2 FSIDNII G 75% 365–372 443 G. gallus AAC60064
  FoxD2 FSIDHIM G 62.5% 409–416 492 M. musculus NP032619
  FoxD2 FSIDHIM G 62.5% 412–419 495 H. sapiens 55956928
  FoxD3 FSIENII G 75% 297–304 371 D. rerio AAC06366
  FoxD3a FSIENII G 75% 297–304 371 X. laevis CAC12963
  FoxD3b FSIENII G 75% 297–304 371 X. laevis CAC12895
  FoxD3 FSIENII G 75% 319–326 394 G. gallus AAC60066
  FoxD3 FSIENII G 75% 366–373 469 M. musculus NM010425
  FoxD3 FSIENII G 75% 378–385 478 H. sapiens NP036315
  FoxD4 FSIESIM Q 62.5% 324–331 408 H. sapiens 18959276
  FoxD4 FTIESIM Q 62.5% 320–327 444 M. musculus 6679841
  FoxD5 FSIDSIM A 62.5% 254–261 321 D. rerio NP571345
  FoxD5a FSIENIM R 62.5% 285–292 352 X. laevis AAD47811
  FoxD5b FSIENIM K 62.5% 285–292 353 X. laevis CAB44729
  FoxD5c FSIENIM G 62.5% 281–288 342 X. laevis CAB44730
E        
  FoxE FSIENII G 75% 207–214 393 C. intestinalis BAC57420
  FoxE1 FRINSLI G 62.5% 202–209 354 D. rerio XP696065
  FoxE1 FRINNLI G 62.5% 206–213 363 T. nigroviridis 47214250
  FoxE1 FSINTLI G 62.5% 231–238 379 X. laevis 46198238
  FoxE3 FSIDNII S 87.5% 269–276 422 D. rerio 118918391
  FoxE3 FSIDSLI N 62.5% 215–222 365 X. laevis 6642989
  FoxE3 FSIDSLI S 62.5% 239–246 383 G. galus 118094619
  FoxE3 FRLDSLL G 50% 195–202 288 M. musculus 7657098
  FoxE3 FSVDSLV P 50% 179–186 385 C. familiaris 73977761
  FoxE3 FSVDSLV N 50% 217–224 319 H. sapiens CAI14973
  FoxE3 FRLDSLL G 50% 193–200 286 R. norvegicus XP233428
  FoxE4 FSIDNII A 75% 227–234 381 B. floridae 18653452
G        
  FoxG1 FSIRRML S 62.5% 20–27 402 B. floridae AF067203
  FoxG1 FSVERLL S 75% 286–293 402 B. floridae AF067203
  FoxG1 FSINSLV P 62.5% 18–25 420 D. rerio 18858707
  FoxG1 FSINSLM P 62.5% 18–25 436 X. laevis AAC79501
  FoxG1 FSINSLV P 62.5% 18–25 451 G. gallus U47275
  FoxG1 FSINSLV P 62.5% 18–25 481 M. musculus AAB42158
  FoxG1 FSINSLV P 62.5% 18–25 480 R. norvegicus 6978845
  FoxG1a FSINSLV P 62.5% 18–25 469 H. sapiens CAA55038
  FoxG1b FSINSLV P 62.5% 18–25 477 H. sapiens X74142
H        
  FoxH1 FAIDSLL H 50% 250–257 472 D. rerio 18858709
  FoxH1 FAIDSLL H 50% 278–285 285 T. nigroviridis 47223489
  FoxH1 FMIDSLL H 50% 271–278 518 X. laevis P70056
  FoxH1 FSIKSLL G 62.5% 198–205 401 R. norvegicus XP235454
  FoxH1 FSIKSLL G 62.5% 167–174 310 B. taurus CAD58794
  FoxH1 FSIKSLL G 62.5% 198–205 401 M. musculus 6679845
  FoxH1 FSIKSLL G 62.5% 194–201 612 H. sapiens 41107639
I        
  FoxI1 FSVNNLI Y 75% 405–412 419 D. rerio AAO63568
  FoxI1c FSVNSLI Y 62.5% 367–374 381 X. laevis CAD31849
  FoxI1c FTVNSLI Y 62.5% 345–352 359 G. gallus 50747424
  FoxI2 FSVNSLI Y 62.5% 369–376 383 D. rerio AAP92808
Q        
  FoxQ1 FSIESIL S 75% 268–275 385 C. intestinalis 70569660
  FoxQ1 FSIDAIL S 75% 226–233 324 B. floridae CAH55831
  FoxQ1 FAIDSIL S 62.5% 177–184 383 D. rerio AAH67139
  FoxQ1 FRIDSLL S 62.5% 276–283 383 D. rerio AAH67139
  FoxQ1 FTIDSIL S 75% 196–203 272 T. nigroviridis 47220396
  FoxQ1 FAIDSIL S 62.5% 224–231 381 X. laevis 76152394
  FoxQ1 FAIDSIL S 62.5% 268–275 400 M. musculus 31560693
  FoxQ1 FAIDSIL S 62.5% 252–259 439 R. norvegicus 12408312
  FoxQ1 FAIDSIL R 50% 270–277 402 H. sapiens 8489093
  FoxQ2 FTIDYLL Y 62.5% 17–24 244 D. rerio XP694156
  FoxQ2 FTIDYLL F 62.5% 20–27 210 T. nigroviridis 47209212
  FoxQ2 FSIDRLV G 62.5% 4–110 271 B. floridae AY163864
L        
  FoxL1 FSIDSIL S 75% 284–291 363 D. rerio 41055835
  FoxL1 FSIDSIL A 62.5% 255–262 336 M. musculus NP032050
  FoxL1 FSIDSIL A 62.5% 259–266 389 R. norvegicus 109508994
  FoxL1 FSIDSIL A 62.5% 262–269 346 B. taurus 61823329
  FoxL1 FSIDSIL A 62.5% 272–279 356 C. familiaris 73956953
  FoxL1 FSIDSIL A 62.5% 261–268 245 H. sapiens 22779860
  1. a The highly conserved core of the eh1-like motifs are indicated in bold.
  2. b The percent similarity between the identified Fox eh1-like motifs and the eh1 motif (FSISNILS) of the Drosophila engrailed homeodomain protein [7].
  3. cThe location of the motifs within the amino acid sequence of the individual Fox proteins.