Figure 21From: In silico comparative genomic analysis of GABAA receptor transcriptional regulationModel for S/MAR associations in GABA A receptor subunit gene locus. (a) Gene locus anchored to nuclear matrix by flanking S/MARS (red) establishes open chromatin conformation. (b) Functional S/MAR mediates loop attachment to transcriptional machinery (pink). (c) Chromatin is reeled through transcriptional machinery in either direction to activate transcription of β2 or α1 gene (d) functional S/MAR dissociates upon elongation. (After Martins et el [15], Heng et al [17]).Back to article page