Figure 5

Detection of MYCN gene amplification in TGW cell line using oligonucelotide arrays. A. DNA copy number changes on chromosome 2. The horizontal axis indicates each locus from 2pter to 2qter, and the vertical axis shows estimated copy number. Gains or losses in DNA copy number are indicated by the blue and red bars, respectively. The brown box depicts the amplified region in chromosome 2 and is expanded in B. B. The region adjacent to the MYCN gene locus highlights chromosomal changes (the brown box region in Fig.5A). The Integrated Genome Browser (IGB) was used for visualization of the data. The horizontal axis indicates chromosome locus, and the vertical axis shows estimated copy number. The two red lines indicate 15.5 M bp and 17.5 M bp, respectively, as in Fig. 4D.