Skip to main content

Table 5 E. histolytica genes downregulated by exposure to Trichostatin A.

From: Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica

Probe ID

GenBank ID

Description

Fold-change

FDR

111.m00118_at

XM_647540

leishmaniolysin-related peptidase, putative

-44.44

0.00E+00

233.m00105_at

XM_645153

hypothetical protein

-29.24

0.00E+00

7.m00429_at

XM_651789

Beige BEACH domain protein, putative

-21.88

8.51E-10

223.m00071_at

XM_645286

hypothetical protein

-10.88

3.04E-04

31.m00224_at

XM_650243

hypothetical protein

-9.43

2.76E-03

1.m00712_at

XM_652408

hypothetical protein

-8.62

1.64E-05

223.m00075_at

XM_645290

lipid phosphatase, putative

-6.71

1.34E-03

105.m00133_at

XM_647680

NADP-dependent alcohol dehydrogenase

-5.81

8.19E-05

223.m00077_x_at

XM_645292

hypothetical protein

-5.65

8.47E-03

585.m00015_s_at

XM_642978

conserved hypothetical protein

-5.52

1.11E-02

223.m00069_at

XM_645284

hypothetical protein

-5.49

9.05E-03

223.m00068_at

XM_645283

scavenger mRNA decapping enzyme, putative

-5.24

2.27E-03

17.m00307_s_at

XM_651008

fatty acid elongase, putative

-5.08

1.34E-02

234.m00042_at

XM_645139

hypothetical protein

-5.00

2.34E-02

66.m00150_at

XM_648887

high mobility group protein, putative

-4.78

3.68E-02

131.m00139_at

XM_647034

M-phase inducer phosphatase, putative

-4.72

2.36E-02

249.m00083_at

XM_644976

hypothetical protein

-4.44

3.58E-03

7.m00436_at

XM_651745

actobindin homolog, putative

-4.31

7.67E-03

223.m00079_at

XM_645294

cysteinyl-tRNA synthetase, putative

-4.20

1.54E-02

425.m00057_s_at

XM_643497

conserved hypothetical protein

-4.10

2.14E-02

223.m00070_at

XM_645285

protein kinase, putative

-4.08

2.28E-02

4.m00636_at

NA

pseudogene, galactose-specific adhesin light subunit

-4.00

4.34E-02

217.m00081_s_at

XM_645388

hypothetical protein

-3.91

1.64E-02

92.m00148_s_at

XM_648072

conserved hypothetical protein

-3.88

4.66E-02

223.m00078_at

XM_645293

ribonuclease, putative

-3.85

3.89E-02

180.m00114_at

XM_646068

hypothetical protein

-3.73

1.75E-03

223.m00067_at

XM_645282

integral membrane protein, putative

-3.73

3.58E-03

223.m00074_at

XM_645289

hypothetical protein

-3.72

1.80E-02

223.m00076_at

XM_645291

hypothetical protein

-3.42

9.24E-03

10.m00362_at

XM_651510

cysteine proteinase, putative

-3.41

3.20E-09

54.m00183_at

XM_649345

hypothetical protein

-3.33

4.69E-02

242.m00078_s_at

XM_645064

cysteine protease 1

-2.89

3.47E-03

77.m00173_at

XM_648536

hypothetical protein

-2.76

2.82E-04

17.m00351_at

XM_651053

galactose-inhibitable lectin 35 kda subunit precursor

-2.75

2.84E-02

9.m00419_at

XM_651593

Fe-hydrogenase, putative

-2.72

1.73E-03

52.m00148_at

XM_649403

lysozyme, putative

-2.61

4.36E-02

154.m00120_at

XM_646541

glucosidase II alpha subunit, putative

-2.57

3.53E-02

9.m00416_at

XM_651590

hypothetical protein

-2.49

4.28E-02

47.m00182_at

XM_649559

fatty acid elongase, putative

-2.26

3.57E-02

22.m00269_s_at

XM_650745

hypothetical protein

-2.19

2.76E-02

77.m00178_s_at

XM_648541

surface antigen ariel1-related

-2.08

3.15E-02

  1. The mean trophozoite expression value for E. histolytica 200:NIH strain under standard culture conditions, the fold-change in TSA treated parasites, FDR, GenBank ID number, and gene annotations are shown. Genes in bold have been confirmed by RT-PCR. Genes regulated during trophozoite to cyst development are shown shaded in italics. Additional loci represented by crosshybridizing _s_at probe sets are as follows: 17.m00307_s_at: 17.m00304; 425.m00057_s_at: 10.m00394; 217.m00081_s_at: 20.m00277; 92.m00148_s_at: 250.m00108 and 284.m00087; 242.m00078_s_at: 79.m00156; 77.m00178_s_at: 19.m00343 and 533.m00017.