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Figure 6 | BMC Genomics

Figure 6

From: Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty

Figure 6

The proposed mechanism underlying the gender difference in kidney function at early puberty. Male gender stimulates growth and proliferation, enhances metabolic and transport activities and therefore elevate oxidative stress. Elevated oxidative stress in form of chronic tubulointerstitial hypoxia causes renal failure by altering tissue structures and function such as the vascular biology by elevating blood pressure, damaging vessels and enhancing blood coagulation.

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