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Figure 5 | BMC Genomics

Figure 5

From: Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution

Figure 5

RARs bind to Alu-DR2 motifs present in retinoic acid responsive genes in vivo. Upper panel: Schematic representation of the promoter regions of selected known retinoic acid-responsive genes containing multiple consensus DR2 RAREs (AGGTCAggAGTTCA) embedded within an Alu repeat sequence. Lower Panel: Results of ChIP assays for RAR binding to promoter regions containing DR2 motifs. DNA from all immunoprecipitates (RAR-specific and control IgG) was amplified under similar conditions (40–42 cycles of PCR).

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