Table 1 Resting NK signature derived from Affymetrix and spotted microarray platform.
| Â | Â | Median fold change (Range) | |
|---|---|---|---|
Gene ontogeny | Gene symbols | Spotted | Affymetrix |
Cell cycle regulators | BTG1, JAG1, MATK, TGFBR3, TINF2, TMEPAI, NEK1, CCND2, CCNC, BIN1, HEXIM1, PPP2R5A, CARF | 2.59 (2.01–5.06) | 3.76 (2.87–7.05) |
Cytotoxicity | CRTAM, CTSW, DPP8, FASLG, FNBP1, GNLY, GZMA, GZMH, HCST, LITAF, PRF1, TNFRSF1B, TNFSF14, NEK1, CASP10, STK17B, CTSC, PRSS23 | 4.48 (2.36–12.76) | 4.43 (2.8–19. 42) |
Cytokines | CCL5, CX3CR1, IL18R1, IL18RAP, IL21R, PPBP(CXCL7) | 7.12 (2.9–17.56) | 5.93 (2.86–29.7) |
Inflammatory response | C3AR1, PDE7A, LY75, RORA, AOAH, ARF6, C1orf38, CLEC2B, IRF1 | 3.12 (2.20–6.56) | 5.06 (2.83–11.01) |
Regulators of immune response | PTPN4(negative regulators), PPP2R2B, SLA2, ID2, KLF11, ZFHX1B | 3.18 (2.36–8.6) | 9.92 (2.84–11.39) |
Secretory pathway and protein maturation | GALNT11, GNPTAB, RAMP1, SEC22L3, SLC38A1, TES, TPST2, WDFY1, GALNT7, DNAJC3, SLC35E1, ZNF12 | 3.88 (2.90–9.01) | 4.34 (3.00–4.96) |
Transcription factors and accessory regulators | BHLHB2, EOMES, KBTBD2, MAF, NFAT5, THRAP3, TXK, ZBTB11, ZNF267, ZNF394, ZNF12, HCF2, MLLT10, MLL3, SSRPN, TAF1, MLR1, ZNF614, EIF2C4, EIF1AY, EIF2C2, | 3.55 (2.58–7.44) | 3.71 (2.88–4.9) |
Regulation of GTPase activity | CENTD1, PLEK, PREX1, RAB7L1, RASGRP1, RGS18, RGS3, RIN3, PCTK2, RAB27B | 4.16 (2.91–5.67) | 4.43 (3.64–6.8) |
Proliferative | GFI1, SMAD5, ZBTB16, AKT3, SMC5L1, RNF139 | 2.90 (2.90–22.16) | 3.02 (3.02–5.3) |
Cytoskeleton orgnisation | DOCK5, DOCK8, DOK2, MACF1, MYOM2, PHLDB2 | 3.41 (2.73–6.21) | 3.51 (2.94–8.50) |
Metabolism and nucleotide biosynthesis | DCY7, ATP6AP2, CHST12, CLIC3, GFOD1, PARP8, TKTL1, YPEL1, ENPP4, DHRS7, BPGM | 2.92 (2.25–19.24) | 4.98 (2.84–9.55) |
Miscellaneous | SBK1, PLAC8, PLCL2, RNF125, SPAG9, MAPK1, C10orf137, C10orf18, C1orf63, C20orf3, FLJ13611, FLJ39739, GALNT10, ZBTB11, BTBD9, C14orf43, BRWD1, FAM62B, BCAP29, C18orf8, LOC285628, KLHL21, KIAA0907, KIAA1450, MOBKL2A, TSPYL1, TRIM39, ULK2, ULK4, WAC, YTHDC2, ZSWIM6 | 4.16 (2.42–10.13) | 4.23 (2.94–8.17) |
Cell adhesion and cell surface | ITGAM, ITGB2, ADAM8, FGR, CD300A(Irp60), CD3Z, CD96, FCER1G, CD94 (KLRD1), CD314 (KLRK1), LAIR2, ADD3, CD244, SPN(CD43), KLRF1 | 3.36 (2.36–8.9) | 3.90 (2.4–21.53) |