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Figure 1 | BMC Genomics

Figure 1

From: Incorporation of genetic model parameters for cost-effective designs of genetic association studies using DNA pooling

Figure 1

Power as a function of number of replicates ( K ) for fixed number of genotypings ( G = J × K ) with recessive mode of inheritance. Power values presented here are for studies with N = 10000, prevalence φ = 0.05, disease allele frequency p d = 0.15, relative risk of homozygous for disease allele R2 = 3, minor SNP marker allele frequency q1 = 0.35, machine replicability variance factor m = 2.25, linkage disequilibrium p r = 0.9 R max 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGWbaCdaWgaaWcbaGaemOCaihabeaakiabg2da9iabicdaWiabc6caUiabiMda5iabdkfasnaaDaaaleaacyGGTbqBcqGGHbqycqGG4baEaeaacqaIYaGmaaaaaa@3A02@ and significance level alpha = 0.0001. *The horizontal line represents the power for specified parameters with individual genotyping using the 2 × 2 test of independence. Power with individual genotyping was computed using the method implemented in the Power for Association With Error (PAWE) website [27].

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