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Table 3 List of parameters considered in the multiple regression analysis

From: Incorporation of genetic model parameters for cost-effective designs of genetic association studies using DNA pooling

Parameter

Description

Value

N

Number of case (control) subjects

1000, 2000, 5000, 10000

φ

Prevalence of the disease

0.01, 0.1

T

Size of the pool

25, 50, 100, 250, 500

K

Number of replicates of each pool

1, 2, 4, 8

p d

Disease allele frequency

0.1, 0.25

MOI

Modes of inheritance

dominant, recessive, multiplicative

R 2

Genotype relative risk of homozygote of disease allele

*1.2, 1.5, 2.25, 4

q 1

Minor SNP marker allele frequency

0.1, 0.35

M

Machine replicability variance factor

2.05, 2.1, 2.25, 3

  1. *R1 is obtained according to the relationship between R1 and R2; that is for multiplicative MOI, R2 = R 1 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGsbGudaqhaaWcbaGaeGymaedabaGaeGOmaidaaaaa@2FE8@ ; dominant MOI, R1 = R2; recessive MOI, R1 = 1. We considered all 30720 (44 × 23 × 3 × 5) situations generated from the parameters listed above.