TY - JOUR AU - Reuveni, Eli AU - Ramensky, Vasily E. AU - Gross, Cornelius PY - 2007 DA - 2007/01/21 TI - Mouse SNP Miner: an annotated database of mouse functional single nucleotide polymorphisms JO - BMC Genomics SP - 24 VL - 8 IS - 1 AB - The mapping of quantitative trait loci in rat and mouse has been extremely successful in identifying chromosomal regions associated with human disease-related phenotypes. However, identifying the specific phenotype-causing DNA sequence variations within a quantitative trait locus has been much more difficult. The recent availability of genomic sequence from several mouse inbred strains (including C57BL/6J, 129X1/SvJ, 129S1/SvImJ, A/J, and DBA/2J) has made it possible to catalog DNA sequence differences within a quantitative trait locus derived from crosses between these strains. However, even for well-defined quantitative trait loci (<10 Mb) the identification of candidate functional DNA sequence changes remains challenging due to the high density of sequence variation between strains. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-8-24 DO - 10.1186/1471-2164-8-24 ID - Reuveni2007 ER -