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Figure 3 | BMC Genomics

Figure 3

From: Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations

Figure 3

Folate synthesis and salvage pathways. Gene names are white-on-gray; all except folQ and PTR1 are from E. coli. The folQ gene has been identified only in Lactococcus lactis and plants, and PTR1 only in Leishmania and other trypanosomatids. Note that DHN aldolase also mediates epimerization of DHN to 7,8-dihydromonapterin and aldol cleavage of 7,8-dihydromonapterin. ADC, aminodeoxychorismate; DHFR, dihydrofolate reductase; DHFS, dihydrofolate synthase; DHNA, dihydroneopterin aldolase; DHNTPase, dihydroneopterin triphosphate pyrophosphatase; DHPS, dihydropteroate synthase; FPGS, folylpolyglutamyl synthase; HPPK, hydroxymethyldihydropterin pyrophosphokinase; NP, nonspecific phosphatase; PTR1, pteridine reductase 1; the subscript ox denotes the fully oxidized forms of pterins.

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BMC Genomics

ISSN: 1471-2164

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