Table 6 List of domains affected by alternative splicing in chromatin-modifying enzymes
From: The functional modulation of epigenetic regulators by alternative splicing
Domain name | Function | Enzyme name |
|---|---|---|
AMINO_OXIDASE | Catalytic | AOF2 |
ANK | Protein-Protein Interaction | EHMT1, EHMT2 |
BRK | Unknown | SMARCA2, SMARCA4 |
BROMO | Interaction (Acetylated Lysines) | SMARCA2, SMARCA4, MLL |
CHROMO | Interaction (Methylated Lysines) | SUV39H1, SUV39H2, Suv39h2, Su(var)3–9, MYST-1, MORF4L1, Morf4l1, Htatip |
DEXHC | Catalytic | SMARCA1, SMARCA2, SMARCA4 |
FAT | Interaction/Modulate catalysis | ATM |
FATC | Interaction/Modulate catalysis | ATM |
FYRC | Probably not-catalytic | MLL, WBP7 |
FYRN | Probably not-catalytic | MLL, WBP7 |
HELICASE_C | SMARCA2 | |
HSA | Probably DNA binding | SMARCA2, SMARCA4 |
JMJC | Catalytic | FBXL11, fbxl10 (from Mus musculus and Xenopus laevis), jmjd1b |
LRR_RI | Interaction | FBXL10 |
MBD | DNA binding | SETDB1, Setdb1 |
MOZ_SAS | Catalytic | Htatip |
MRG | Interaction | MORF4L1 |
PCAF_N | Interaction with CBP | GCN5L2 |
PHD | Intra- and Intermolecular interactions | MLL, MLL2, MLL3, JMJD2B, Jmjd2a, WBP7 |
PI3_PI4_KINASE | Catalytic | PRKDC, ATM |
PKINASE | Catalytic | AURKB, GSG2, RPS6KA5, stk4 |
PRESET | Interaction-Catalysis | SUV39H1, SUV39H2, Suv39h2, Su(var)3–9, SETDB1, Setdb1, EHMT1, EHMT2 |
PWWP | Unknown | NSD1 |
RING | Interaction | MLL2, RNF40 |
SET | Catalytic | PRDM2, SUV39H1, SUV39H2, suv39h2, Su(var)3–9,SETDB1, Setdb1, mez2, MLL, WBP7, EHMT1, EHMT2, EZH2 |
SKB1 | Catalytic | CARM1 |
UBCC | Whole protein | UBE2A |
TUDOR | Interaction | Jmjd2a, Jmjd2b, JMJD2B, SETDB1, Setdb1 |
ZF_C3HC4 | Interaction | RNF40 |
ZF_CXXC | Interaction | Fbxl10, Fbxl11, MLL, WBP7, |
ZNF_TAZ | Interaction | cbp-1 |